Cytokine Removal and Immunomodulation in COVID-19 Severe Pulmonary Respiratory Infection
| Autor: | Courville, Karen, Pechio, Maydelin, Bustamante, Norman |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Lung
biology business.industry medicine.medical_treatment Respiratory infection medicine.disease_cause medicine.disease Proinflammatory cytokine coronavirus cytokine hemofiltration adsorption corticosteroid immunomodulation cytokine storm IL-6 medicine.anatomical_structure Cytokine Immunology Hemofiltration medicine biology.protein Cytokine storm business Interleukin 6 Coronavirus |
| DOI: | 10.14293/s2199-1006.1.sor-.ppwlc61.v1 |
| Popis: | Coronavirus infection produces a cytokine storm in some patients, developing a moderate to severe clinical condition that is associated to increased mortality mainly because of severe pulmonary involvement. Elevated levels of IL-6 have been found in non-survivor patients. In these patients, clearance of cytokines with extracorporeal therapies, Pulse High- Volume Hemofiltration together with adsorption columns Cytosorb, in short periods of time for 1 to 3 days, could help remove inflammatory cytokines allowing a downregulation of the inflammatory response; and, at the same time, treatment with low dose steroids, could give an opportunity for the host to reach homeostasis, decreasing lung damage and improving survival. |
| Databáze: | OpenAIRE |
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