Ketogenic diet for infantile spasms refractory to first-line treatments: an open prospective study
| Autor: | Stéphane Auvin, Emilie Bourel, Adina Ilea, Vanina Bellavoine, Dana Merdariu, Maria Elisa Pires, Patrick Berquin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Topiramate
Male Pediatrics medicine.medical_specialty medicine.medical_treatment Population Vigabatrin Felbamate Cohort Studies Epilepsy medicine Humans Prospective Studies Prospective cohort study education education.field_of_study business.industry Infant medicine.disease Treatment Outcome Neurology Tolerability Female Neurology (clinical) business Diet Ketogenic Spasms Infantile Ketogenic diet medicine.drug Follow-Up Studies |
| Zdroj: | Epilepsy research. 105(1-2) |
| ISSN: | 1872-6844 |
| Popis: | Summary Ketogenic diet (KD) is an efficient treatment for refractory epilepsy including infantile spasms (IS). We evaluated the effect of a KD to treat IS as a third-line treatment, after vigabatrin (VGB) and steroids. We evaluated the efficacy and the tolerability of KD in IS using the rate of seizure-free patients at 1 month. Methods We conducted an open study using the data from a prospective database of two French child neurology departments (Amiens & Robert Debre-Paris, France) over a three-year period. All the patients followed the KD for 6 months. The addition of an antiepileptic drug was allowed after 1 month of KD in the non-seizure-free patients. Results 17 patients were treated by KD for IS. The KD was initiated at the mean age of 9.4 ± 1.1 months. After 1 month with KD, 6/17 (35%) patients were seizure free while 11/17 (65%) were seizure-free after the third month. However, an additional antiepileptic drug (felbamate or topiramate) was given to all patients that were not seizure-free under KD. The KD was well tolerated. Conclusion Our responder rate is similar to previous studies despite an early use (before 1-year-old) and the use of KD after VGB and steroids. The KD was well-tolerated in this population of young infants. Felbamate leads to an increase in the responder rate after the use of KD. |
| Databáze: | OpenAIRE |
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