Pathogenic Role of Epstein-Barr Virus in Lung Cancers
| Autor: | Ramsy Abdelghani, Janardhan Avilala, David Becnel, Li Li, Jacob Kahn, Zhen Lin, Asuka Nanbo |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Gene Expression Regulation Viral Epstein-Barr Virus Infections Herpesvirus 4 Human Lung Neoplasms Review medicine.disease_cause NSCLC Microbiology Virus Epstein–Barr virus 03 medical and health sciences 0302 clinical medicine EBV Virology hemic and lymphatic diseases medicine Animals Humans Clinical significance non-small cell lung cancer Lung business.industry Cancer SCLC medicine.disease Cell Transformation Viral QR1-502 Virus Latency Disease Models Animal 030104 developmental biology Infectious Diseases medicine.anatomical_structure 030220 oncology & carcinogenesis NGS Immunology Etiology next-generation sequencing Disease Susceptibility small cell lung cancer business Carcinogenesis Oncovirus |
| Zdroj: | Viruses Viruses, Vol 13, Iss 877, p 877 (2021) |
| ISSN: | 1999-4915 |
| Popis: | Human oncogenic viruses account for at least 12% of total cancer cases worldwide. Epstein–Barr virus (EBV) is the first identified human oncogenic virus and it alone causes ~200,000 cancer cases and ~1.8% of total cancer-related death annually. Over the past 40 years, increasing lines of evidence have supported a causal link between EBV infection and a subgroup of lung cancers (LCs). In this article, we review the current understanding of the EBV-LC association and the etiological role of EBV in lung carcinogenesis. We also discuss the clinical impact of the knowledge gained from previous research, challenges, and future directions in this field. Given the high clinical relevance of EBV-LC association, there is an urgent need for further investigation on this topic. |
| Databáze: | OpenAIRE |
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