The in vivo release of 90Y from cyclic and acyclic ligand-antibody conjugates
| Autor: | Nigel Robert Arnold Beeley, C Walker, Andrew S. Craig, SK Rhind, A Turner, J.M. Sansom, Amanda M. Randall, Alice Harrison, Jonathan P. L. Cox, Kenneth Millar, David Parker, Michael Anthony William Eaton, L. Chaplin, R.A. Boyce, A Farnsworth, Karl J. Jankowski, Andrew T. Millican, D.S. Secher |
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| Rok vydání: | 1991 |
| Předmět: |
Male
medicine.drug_class Stereochemistry Mice Inbred Strains Conjugated system Ligands Monoclonal antibody Bone and Bones Heterocyclic Compounds 1-Ring Mice chemistry.chemical_compound Bone Marrow Heterocyclic Compounds In vivo medicine Animals DOTA Yttrium Radioisotopes neoplasms biology Ligand Antibodies Monoclonal General Medicine Pentetic Acid Molecular biology chemistry Immunoglobulin G Isotope Labeling biology.protein Liberation Antibody Conjugate |
| Zdroj: | International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 18:469-476 |
| ISSN: | 0883-2897 |
| DOI: | 10.1016/0883-2897(91)90107-v |
| Popis: | Yttrium binding ligands DOTA, caDTPA and CT-DTPA were each conjugated to monoclonal antibody B72.3, labelled with 90 Y and injected into mice in order to assess the in vivo inertness of the antibody-linked 90 Y-ligand complexes. Levels of 90 Y in femur shafts of the DOTA-B72.3 mice were low, being ~ 7 and 44%, respectively, of levels in the femur shafts of the caDTPA-B72.3 and CT-DTPA-B72.3 treated mice. This finding demonstrates the greater inertness and by implication the greater suitability for immunotherapy of the DOTA- 90 Y complex. |
| Databáze: | OpenAIRE |
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