Estrogen Receptor 1 Gene (ESR1) is Associated with Restrictive Anorexia Nervosa
| Autor: | Anke Hinney, Susann Scherag, Claudette Boni, Johannes Hebebrand, Lucia Romo, Audrey Versini, Julien-Daniel Guelfi, Philip Gorwood, Yann Le Strat, Stefan Ehrlich, Nicolas Ramoz |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Anorexia Nervosa Adolescent Genotype Population Medizin Single-nucleotide polymorphism Genome-wide association study Biology Polymorphism Single Nucleotide Statistics Nonparametric White People Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Germany Internal medicine medicine Humans Genetic Predisposition to Disease Child education Family Health 2. Zero hunger Pharmacology education.field_of_study Haplotype Estrogen Receptor alpha Transmission disequilibrium test Odds ratio medicine.disease 3. Good health 030227 psychiatry body regions Psychiatry and Mental health Eating disorders Endocrinology Psychologie Anorexia nervosa (differential diagnoses) Original Article Female France 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | Neuropsychopharmacology. 35:1818-1825 |
| ISSN: | 1740-634X 0893-133X |
| Popis: | Anorexia nervosa (AN) is a highly heritable young-onset psychiatric illness the etiology of which remains unknown. Estrogen alpha and beta receptors, encoded by ESR1 and ESR2 genes, are involved in food intake regulation and eating behavior, and may have a potential role in AN. We performed a family-based association study of 17 single-nucleotide polymorphisms (SNPs) encompassing ESR1 and ESR2 genes in a cohort of 321 French AN families. We attempted to replicate this finding in a cohort of 41 restrictive AN (RAN) families and in a population-based study of 693 young women. Using the transmission disequilibrium test, a significant over-transmission was detected between AN and ESR1 rs726281 and rs2295193. These SNPs and another among ESR1 were more specifically associated with the RAN subtype (rs726281, p=0.005, odds ratio (OR)=2.1, 95% confidence interval (95% CI)=1.2–3.6; rs3798577, p=0.021, OR=1.6, 95% CI=1.1–2.3; and rs2295193, p=0.007, OR=1.7, 95% CI=1.2–2.5). A large eight-SNPs haplotype of ESR1 gene was also associated with AN (p |
| Databáze: | OpenAIRE |
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