Treatment outcome of tuberculosis patients detected using accelerated vs. passive case finding in Myanmar
Autor: | T H Aung, P S Khaing, H M Oo, Kyaw Thu Soe, Khine Wut Yee Kyaw, Saw Thein, Srinath Satyanarayana, Si Thu Aung, T Thwin, Nay Lynn Oo, Nang Thu Thu Kyaw |
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Rok vydání: | 2018 |
Předmět: |
Adult
Male 0301 basic medicine Pulmonary and Respiratory Medicine medicine.medical_specialty Tuberculosis Adolescent HIV Positivity 030106 microbiology Treatment outcome Antitubercular Agents Myanmar digestive system Young Adult 03 medical and health sciences Tuberculosis diagnosis Internal medicine medicine Humans Mass Screening Young adult Child Aged Retrospective Studies Aged 80 and over business.industry Infant Newborn Sputum Infant Retrospective cohort study Middle Aged medicine.disease digestive system diseases Treatment Outcome Infectious Diseases Child Preschool Relative risk Female medicine.symptom business Case Management |
Zdroj: | The International Journal of Tuberculosis and Lung Disease. 22:1145-1151 |
ISSN: | 1027-3719 |
Popis: | Setting Several projects involving accelerated or active case finding (ACF) of tuberculosis (TB) cases are being implemented in Myanmar. However, there is a concern that patients detected using ACF have poorer TB treatment outcomes than those detected using passive case finding (PCF). Objective To assess differences in the demographics, clinical profile and treatment outcomes of patients detected using ACF and PCF. Design Retrospective cohort study of TB patients diagnosed and enrolled for treatment during 2014-2016. Results Of 16 048 patients enrolled, 2226 (16%) were detected using ACF; the treatment success rate (cured and completed) was 88%. A higher proportion of cases detected using ACF were aged 55 years, human immunodeficiency virus (HIV) negative and sputum smear-positive pulmonary TB. After adjusting for differences in demographic and clinical characteristics, we found that treatment outcomes in patients detected using ACF and PCF were not significantly different (adjusted relative risk [aRR] 0.89, 95%CI 0.78-1.00). Male sex, age 55 years, patients with a previous history of TB and HIV positivity were independently associated with unsuccessful outcomes. Conclusion ACF detected a significant proportion of TB cases in study townships; treatment outcomes in cases detected using ACF and those detected using PCF were similar. More tailored interventions are needed to improve treatment outcomes in patients at a higher risk of unsuccessful treatment outcomes. |
Databáze: | OpenAIRE |
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