Insight Into the Pathogenesis of Fetal Growth Restriction in Placental Malaria: Decreased Placental Glucose Transporter Isoform 1 Expression
| Autor: | Caroline Lin Lin Chua, Ebbie Chaluluka, Philippe Boeuf, Alexandra J. Umbers, Stephen J. Rogerson, Jocelyn D. Glazier, Upeksha P. Chandrasiri |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Adolescent Placenta Biology Pathogenesis Young Adult Syncytiotrophoblast Pregnancy Internal medicine parasitic diseases Biopsy medicine Humans Immunology and Allergy Malaria Falciparum Glucose Transporter Type 1 Fetal Growth Retardation medicine.diagnostic_test Infant Newborn Glucose transporter Transplacental Basal plasma membrane Infectious Diseases medicine.anatomical_structure Endocrinology Gene Expression Regulation Pregnancy Complications Parasitic embryonic structures Female |
| Zdroj: | The Journal of Infectious Diseases. 209:1663-1667 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jit803 |
| Popis: | Placental malaria, especially when complicated with intervillositis, can cause fetal growth restriction. Transplacental glucose transport by glucose transporter isoform 1 (GLUT-1) on the syncytiotrophoblast microvillous and basal plasma membranes regulates fetal growth. We found that GLUT-1 expression in the microvillous plasma membrane of Plasmodium falciparum-negative placenta biopsy specimens was comparable to that in P. falciparum-positive placenta biopsy specimens with or without intervillositis, whereas GLUT-1 expression in the basal plasma membrane was lowest in P. falciparum-positive placenta biopsy specimens with intervillositis, compared with the other 2 specimen types (P ≤ .0016). GLUT-1 expression in the basal plasma membrane also correlated negatively with monocyte infiltrate density (r = -0.43; P = .003) and positively with birth weight (r = 0.28; P = .06). These findings suggest that intervillositis, more than placental malaria per se, might cause fetal growth restriction, through impaired transplacental glucose transport. |
| Databáze: | OpenAIRE |
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