Modified total lymphoid irradiation and low dose corticosteroids in progressive multiple sclerosis
| Autor: | S. Bansil, George Zito, Corinne Devereux, T. Volmer, J. Boos, P. Dowling, Joseph Guarnaccia, Leo J. Wolansky, Christine Rohowsky-Kochan, Jonathan Goldstein, Stuart D. Cook, Raymond Troiano, B. Haffty, A. Jotkowitz, Amiram Sheffet |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Multiple Sclerosis Randomization medicine.drug_class medicine.medical_treatment Gastroenterology law.invention Placebos Double-Blind Method Randomized controlled trial law Prednisone Internal medicine medicine Humans Prospective Studies Glucocorticoids Survival analysis Probability Chemotherapy Expanded Disability Status Scale business.industry Patient Selection Multiple sclerosis medicine.disease Combined Modality Therapy Magnetic Resonance Imaging Survival Analysis Surgery Neurology Corticosteroid Female Neurology (clinical) business Whole-Body Irradiation Follow-Up Studies medicine.drug |
| Zdroj: | Journal of the Neurological Sciences. 152:172-181 |
| ISSN: | 0022-510X |
| DOI: | 10.1016/s0022-510x(97)00189-5 |
| Popis: | In a double-blind prospective randomized trial, we assessed the efficacy and safety of modified total lymphoid irradiation (TLI) plus low dose prednisone (TLI-LDP) as compared to sham TLI plus identical prednisone therapy (sham TLI-LDP) in 46 patients with progressive forms of multiple sclerosis (MS). No significant difference existed between groups at study entry in patient age, sex, duration of MS, or disability status. However, following treatment, significantly fewer TLI patients showed a sustained one point decline in the Expanded Disability Status Scale, the primary study endpoint, as compared to the sham TLI group using the Kaplan-Meier Product-limit survival analysis, (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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