An investigation of clinical and immunological events following repeated aerodigestive tract challenge infections with live Mycobacterium bovis Bacille Calmette Guerin
| Autor: | David J. M. Lewis, Nicola Fenner, Maria Woodrow, Fernanda Schreiber, Steven Prideaux, Zhiming Huo, Gordon Dougan, Rafaela Giemza, Luiz R.R. Castello-Branco, Zoe Stephens |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Tuberculosis Adolescent T-Lymphocytes 030231 tropical medicine Biology Article 03 medical and health sciences 0302 clinical medicine Immune system Immunology and Microbiology(all) Oral challenge medicine Humans BCG Tuberculosis Vaccines Innate immunity Mycobacterium Infections 0303 health sciences Mycobacterium bovis Reactogenicity General Veterinary General Immunology and Microbiology 030306 microbiology Public Health Environmental and Occupational Health virus diseases Middle Aged biology.organism_classification medicine.disease Virology veterinary(all) Immunity Innate 3. Good health Vaccination Intestinal Diseases Infectious Diseases Immunization Immunology Molecular Medicine Female Tuberculosis vaccines BCG vaccine |
| Zdroj: | Vaccine |
| ISSN: | 0264-410X |
| Popis: | Bacille Calmette Guérin substrain Moreau Rio de Janeiro is an attenuated strain of Mycobacterium bovis that has been used extensively as an oral tuberculosis vaccine. We assessed its potential as a challenge model to study clinical and immunological events following repeated mycobacterial gut infection. Seven individuals received three oral challenges with approximately 107 viable bacilli. Clinical symptoms, T-cell responses and gene expression patterns in peripheral blood were monitored. Clinical symptoms were relatively mild and declined following each oral challenge. Delayed T-cell responses were observed, and limited differential gene expression detected by microarrays. Oral challenge with BCG Moreau Rio de Janeiro vaccine was immunogenic in healthy volunteers, limiting its potential to explore clinical innate immune responses, but with low reactogenicity. |
| Databáze: | OpenAIRE |
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