Antidepressant activity of astilbin: involvement of monoaminergic neurotransmitters and BDNF signal pathway
Autor: | Wen-Jie Wu, Rui-Li Liu, Qiong-Qiong Lv, Xiao-Liang Guo, Du-Shuang Zhou, Ji-Xia Zhang, Ju-Yuan Liu, Yu-Ping Yang |
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Rok vydání: | 2014 |
Předmět: |
Male
medicine.medical_specialty Serotonin Flavonols Dopamine Pharmaceutical Science Pharmacology Motor Activity chemistry.chemical_compound Food Preferences Neurotrophic factors Monoaminergic medicine Animals Biogenic Monoamines Psychiatry Swimming Brain-derived neurotrophic factor Behavior Animal business.industry Brain-Derived Neurotrophic Factor General Medicine Tail suspension test Antidepressive Agents Mice Inbred C57BL Disease Models Animal chemistry Chronic Disease Antidepressant Astilbin business Stress Psychological Behavioural despair test Signal Transduction |
Zdroj: | Biologicalpharmaceutical bulletin. 37(6) |
ISSN: | 1347-5215 |
Popis: | Depression and related mood disorders are among the world's greatest public health problems. Previous studies have demonstrated that astilbin (AST) has broad pharmacological functions which may modulate numerous pathways, such as antioxidant, scavenging free radicals, anti-inflammatory and so on, similarly to some of other flavonoids. In this study, the antidepressant-like effect of AST was investigated using chronic unpredictable mild stress (CUMS) model of depression in mice. The results showed that chronic administration of AST at doses of 10, 20 and 40 mg/kg (intraperitoneally (i.p.), 21 d) reduced depressive-like behaviors of mice in the forced swim test (FST), tail suspension test (TST) and sucrose preference test (SPT) without affecting locomotor activity. AST increased the contents of serotonin (5-HT) and dopamine (DA) in the frontal cortex of CUMS mice. Additionally, it was shown that AST treatment restored the CUMS-induced inhibition of extracellular signal-regulated kinase (ERK) 1/2 and AKT phosphorylation in the frontal cortex, conformed to the brain-derived neurotrophic factor (BDNF) expression. Our findings suggest that AST has antidepressant activities and the mechanisms, at least in part, relate to up-regulation of monoaminergic neurotransmitters (5-HT and DA) and activation of the BDNF signaling pathway. |
Databáze: | OpenAIRE |
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