Effects of Substituents on the Photophysical/Photobiological Properties of Mono-Substituted Corroles

Autor:	Vitória Barbosa de Souza, Vinícius N. da Rocha, Paulo Cesar Piquini, Otávio Augusto Chaves, Bernardo A. Iglesias
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Chemistry (miscellaneous) Organic Chemistry Drug Discovery trans-A2B-corroles Molecular Medicine Pharmaceutical Science photobiology Physical and Theoretical Chemistry corroles Analytical Chemistry photophysics
Zdroj:	Molecules Volume 28 Issue 3 Pages: 1385
ISSN:	1420-3049
DOI:	10.3390/molecules28031385
Popis:	The trans-A2B-corrole series was prepared starting with 5-(pentafluorophenyl)dipyrromethene, which was then reacted with respective aryl-substituted aldehyde by Gryko synthesis. It was further characterized by HRMS and electrochemical methods. In addition, we investigated experimental photophysical properties (absorption, emission by steady-state and time-resolved fluorescence) in several solvents and TDDFT calculations, aggregation, photostability and reactive oxygen species generation (ROS), which are relevant when selecting photosensitizers used in photodynamic therapy and many other photo-applications. In addition, we also evaluated the biomolecule-binding properties with CT-DNA and HSA by spectroscopy, viscometry and molecular docking calculations assays.
Databáze:	OpenAIRE
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