The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome

Autor: Emma J. Crosbie, Neil A.J. Ryan, Mark J. Arends, Tjalling Bosse, John Burn, Joanna M. Cornes, Robin Crawford, Diana Eccles, Ian M. Frayling, Sadaf Ghaem-Maghami, Heather Hampel, Noah D. Kauff, Henry C. Kitchener, Sarah J. Kitson, Ranjit Manchanda, Raymond F.T. McMahon, Kevin J. Monahan, Usha Menon, Pål Møller, Gabriela Möslein, Adam Rosenthal, Peter Sasieni, Mourad W. Seif, Naveena Singh, Pauline Skarrott, Tristan M. Snowsill, Robert Steele, Marc Tischkowitz, Angel Alonso Sanchez, James Bolton, David Church, Karen Donnelly, Richard J. Edmondson, D. Gareth Evans, Paula Gollop, Selina Goodman, Shirley Hodgson, Fiona Lalloo, Anne Lowry, Rhona J. McVey, Tracie Miles, Gabriela Moeslein, Pal Moller, Astrid Stormoken, Helen Stringfellow, Andrew Wallace, Luciya Whyte, Nafisa Wilkinson, Godfrey Wilson, Jo Wilson, Nick Wood
Jazyk: angličtina
Rok vydání: 2019
Předmět:
MICROSATELLITE INSTABILITY
0302 clinical medicine
Colorectal Neoplasms
Hereditary Nonpolyposis/epidemiology
Endometrial Neoplasms/epidemiology
Mass Screening
MUTATION
Genetics (clinical)
Early Detection of Cancer
Ovarian Neoplasms
Genetics & Heredity
RISK
0303 health sciences
Manchester Cancer Research Centre
CLINICAL-CRITERIA
WOMEN
NONPOLYPOSIS COLORECTAL-CANCER
TUMORS
Lynch syndrome
3. Good health
Europe
030220 oncology & carcinogenesis
endometrial cancer
surveillance
Female
Ovarian Neoplasms/epidemiology
Life Sciences & Biomedicine
guidance
medicine.medical_specialty
congenital
hereditary
and neonatal diseases and abnormalities
Consensus
Genital Neoplasms
Female
QUALITY-ASSURANCE
Best practice
OVARIAN-CANCER
Unmet needs
03 medical and health sciences
Special Article
medicine
Humans
030304 developmental biology
0604 Genetics
Science & Technology
business.industry
Endometrial cancer
ResearchInstitutes_Networks_Beacons/mcrc
screening
nutritional and metabolic diseases
1103 Clinical Sciences
medicine.disease
Gynecological cancer
Colorectal Neoplasms
Hereditary Nonpolyposis
digestive system diseases
Endometrial Neoplasms
Family medicine
Expert opinion
Manchester International Consensus Group
North America
Genital Neoplasms
Female/epidemiology
business
Zdroj: Crosbie, E J, Ryan, N A J, Arends, M, Bosse, T, Burn, J, Cornes, J M, Crawford, R A F, Eccles, D, Frayling, I M, Ghaem-Maghami, S, Hampel, H, Kauff, N, Kitchener, H C, Kitson, S J, Manchanda, R, McMahon, R F T, Monahan, K J, Menon, U, Moller, P, Moeslein, G, Rosenthal, A N, Sasieni, P, Seif, M W, Singh, N, Skarrott, P, Snowsill, T M, Steele, R J, Tischkowitz, M D & Evans, D G R 2019, ' The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome ', Genetics in Medicine . https://doi.org/10.1038/s41436-019-0489-y
2019, ' The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome ', Genetics in Medicine, vol. 21, no. 10, pp. 2390-2400 . https://doi.org/10.1038/s41436-019-0489-y
Genetics in Medicine, 21(10), 2390-2400
Crosbie, E, Ryan, N, Evans, D G, Edmondson, R & et al. 2019, ' The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome ', Genetics in Medicine . https://doi.org/10.1038/s41436-019-0489-y, https://doi.org/10.1038/s41436-019-0489-y
Genetics in Medicine
ISSN: 1098-3600
Popis: Purpose\ud \ud There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients.\ud \ud Methods\ud \ud Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice.\ud \ud Results\ud \ud Guidance was developed in four key areas: (1) whether women with gynecological cancer should be screened for Lynch syndrome and (2) how this should be done, (3) whether there was a role for gynecological surveillance in women at risk of Lynch syndrome, and (4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer.\ud \ud Conclusion\ud \ud This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.
Databáze: OpenAIRE
Externí odkaz: