The influence of terpinen-4-ol and eucalyptol – The essential oil components - on fungi and plant sterol monolayers
| Autor: | Marcin Broniatowski, Aneta Wójcik, Paweł Wydro, Katarzyna Hąc-Wydro, Karolina Połeć, Michał Flasiński |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Surface Properties
Biophysics 02 engineering and technology Biochemistry law.invention Terpene 03 medical and health sciences chemistry.chemical_compound X-Ray Diffraction law Monolayer Oils Volatile polycyclic compounds Organic chemistry Essential oil 030304 developmental biology Microscopy 0303 health sciences Ergosterol Eucalyptol Terpenes Chemistry Terpinen-4-ol Fungi Phytosterols Cell Biology 021001 nanoscience & nanotechnology Sterol Sterols Membrane lipids (amino acids peptides and proteins) 0210 nano-technology |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Biomembranes. 1861:1093-1102 |
| ISSN: | 0005-2736 |
| DOI: | 10.1016/j.bbamem.2019.03.015 |
| Popis: | Antifungal and herbicidal activity of terpenes, being the components of the essential oils, is directly related to the incorporation of these compounds into cellular membranes. Thus, the differences in the lipid composition of various pathogenic membranes may be the factor determining the activity of these molecules. One of the class of lipids, which form the membrane environment are sterols. The aim of this work was to compare the effect of two terpenes: terpinen-4-ol and eucalyptol on the monolayers formed by ergosterol and β - sitosterol, which are the components of fungi and plant membranes, respectively. The modifications in the sterol monolayer properties were investigated in the surface pressure-area measurements and penetration studies as well as in a micrometer scale (Brewster angle microscopy experiments) and in nanoscale (GIXD technique). It was evidenced that although at higher surface pressure the terpene molecules are in part removed from the interface, they are able to substantially modify the condensation, morphology and molecular organization of the sterol film. It was also found that the incorporation of terpenes into sterol films is comparable for both sterols, however, β - sitosterol monolayers properties are affected more strongly than ergosterol films. Finally, the analysis of the results of the studies performed on model membrane systems and the results of antimicrobial studies reported in literature, enabled us to suggest that the activity of terpenes depends on the membrane composition and that the sterol concentration may be important from the point of view of antifungal effect of terpinen-4-ol and eucalyptol. |
| Databáze: | OpenAIRE |
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