Does low-dose aspirin initiated before 11 weeks' gestation reduce the rate of preeclampsia?
| Autor: | Maria N Plana, Liona C. Poon, Diana Cuenca-Gomez, M. M. Gil, Piya Chaemsaithong |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Complications of pregnancy Gestational hypertension Preeclampsia law.invention 03 medical and health sciences 0302 clinical medicine Pre-Eclampsia Randomized controlled trial Pregnancy Antiphospholipid syndrome law Internal medicine In vitro fertilization Recurrent miscarriage Humans Medicine Thrombophilia 030212 general & internal medicine Aspirin 030219 obstetrics & reproductive medicine business.industry Fetal growth restriction Infant Newborn Pregnancy Outcome Abortion Obstetrics and Gynecology General Medicine medicine.disease Clinical trial Recurrent pregnancy loss Pregnancy Trimester First Treatment Outcome Relative risk Hypertension Systematic review Female business Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | DDFV: Repositorio Institucional de la Universidad Francisco de Vitoria Universidad Francisco de Vitoria DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria instname |
| Popis: | OBJECTIVE: DATA: Pre-conception or early administration of low-dose aspirin might improve endometrial growth, placental vascularization and organogenesis. Most studies have evaluated the potential benefit of pre-conception or early administration of low-dose aspirin in women with a history of recurrent pregnancy loss, women who have undergone in vitro fertilization or women with thrombophilia or antiphospholipid syndrome. These women are at an increased risk of placenta-associated complications of pregnancy, including preeclampsia, preterm delivery and fetal growth restriction. STUDY: We performed a systematic review and meta-analysis to evaluate the effect of low-dose aspirin initiated at 85% of the study population. Relative risks (RR) with 95% confidence intervals (CI) were calculated for each study and pooled for global analysis as the effect measure. We assessed statistical heterogeneity in each meta-analysis using the Chi2 statistics, I2 and Tau2. Heterogeneity was considered substantial if an I2 was greater than 50% and either the Tau2 was greater than zero, or there was a low P-value ( |
| Databáze: | OpenAIRE |
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