Pulmonary injury as a predictor of cerebral hypoxia in traumatic brain injury: from physiology to physiopathology

Autor:	Randy Reina-Rivero, Natalia Paéz-Escallón, Michael Gregorio Ortega-Sierra, Anyull Bohorquez-Caballero, Ivan David Lozada-Martínez, Tariq Janjua, Luis Rafael Moscote-Salazar, Laura Acevedo-Aguilar, Maria Daniela Del Pilar Zambrano-Arenas, Gustavo Gaitan-Herrera
Rok vydání:	2022
Předmět:	Traumatic brain injury business.industry Acute Lung Injury Cerebral hypoxia Lung injury medicine.disease Bioinformatics Pathophysiology Clinical Practice Brain Injuries Traumatic medicine Humans Surgery Pulmonary Injury Neurology (clinical) Hypoxia Brain business Therapeutic strategy
Zdroj:	Journal of Neurosurgical Sciences. 66
ISSN:	1827-1855 0390-5616
Popis:	Traumatic brain injury is caused by mechanical forces impacting the skull and its internal structures and constitutes one of the main causes of morbidity and mortality in the world. Clinically, severe traumatic brain injury is associated with the development of acute lung injury and so far, few studies have evaluated the cellular, molecular and immunological mechanisms involved in this pathophysiological process. Knowing and investigating these mechanisms allows us to correlate pulmonary injury as a predictor of cerebral hypoxia in traumatic brain injury and to use this finding in decision making during clinical practice. This review aims to provide evidence on the importance of the pathophysiology of traumatic brain injury-acute lung injury, and thus confirm its role as a predictor of cerebral hypoxia, helping to establish an appropriate therapeutic strategy to improve functional outcomes and reduce mortality.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c232406cd4dfb6eb7e89533800153b https://doi.org/10.23736/s0390-5616.21.05468-0 Zobrazit plný text záznamu