Stereoselective degradation of metalaxyl and metalaxyl-M in soil and sunflower plants
| Autor: | Cesare Marucchini, Claudia Zadra |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Pharmacology
Chromatography Alanine Organic Chemistry Enantioselective synthesis Stereoisomerism Sunflower Catalysis Analytical Chemistry Fungicides Industrial Fungicide chemistry.chemical_compound Biodegradation Environmental chemistry Drug Discovery Helianthus Soil Pollutants Enantiomer Racemization Metalaxyl Soil microbiology Spectroscopy Soil Microbiology |
| Zdroj: | Chirality. 14(1) |
| ISSN: | 0899-0042 |
| Popis: | A high proportion of agrochemicals are chiral compounds. Since stereoisomers often show different biological and physiological properties, the biological and metabolic responses to these compounds and their fate in the environment are expected to be different. In this work we investigate a possible stereo and/or enantioselective degradation in soil and plants (sunflower) of the fungicide Metalaxyl (rac-Metalaxyl) and the new compound Metalaxyl-M ((-)-(R)-Metalaxyl) and propose procedures for extraction, cleanup, chromatographic separation of enantiomers, and determination of the R : S ratio by using an HPLC chiral column. The degradation of the two stereoisomers of Metalaxyl proved to be enantioselective and dependent on the media: the (+)-(S)-enantiomer showed a faster degradation in plants, while the (-)-(R)-enantiomer showed a faster degradation in soil. In this study there was no evidence that racemization of Metalaxyl-M took place either in soil or in sunflowers. |
| Databáze: | OpenAIRE |
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