(S)-(-)-Bromofosfamide (CBM-11): synthesis and antitumor activity and toxicity in mice
| Autor: | Konrad Misiura, H Kuśnierczyk, W J Stec, R W Kinas, Czeslaw Radzikowski |
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| Rok vydání: | 2001 |
| Předmět: |
Cancer Research
Injections Subcutaneous Melanoma Experimental Biological Availability Pharmacology Carcinoma Lewis Lung Mice Carcinoma medicine Animals Pharmacology (medical) Ifosfamide Leukemia L1210 Antineoplastic Agents Alkylating Chromatography High Pressure Liquid Crosses Genetic Antitumor activity Molecular Structure Chemistry musculoskeletal neural and ocular physiology Melanoma medicine.disease Mice Inbred C57BL Oncology Mice Inbred DBA Toxicity Bromofosfamide Female medicine.drug Biological availability |
| Zdroj: | Anti-cancer drugs. 12(5) |
| ISSN: | 0959-4973 |
| Popis: | (S)-(-)-Bromofosfamide (CBM-11), an enantiomerically pure bromo analog of ifosfamide, was found to be potent against several model tumors in mice. Therapeutic indices of CBM-11 were more favorable as compared to those received for ifosfamide. |
| Databáze: | OpenAIRE |
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