Control of gastrula cell motility by the Goosecoid/Mix.1/ Siamois network: basic patterns and paradoxical effects
| Autor: | Martina Nagel, Olivia Luu, Patrick Lemaire, Stephan A. Wacker, Rudolf Winklbauer |
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| Přispěvatelé: | Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
animal structures
Xenopus Motility [SDV.BC]Life Sciences [q-bio]/Cellular Biology Xenopus Proteins Xenopus laevis 03 medical and health sciences 0302 clinical medicine Cell Movement Cell polarity Animals 10. No inequality Transcription factor 030304 developmental biology Homeodomain Proteins Genetics 0303 health sciences biology fungi Cell Polarity Gene Expression Regulation Developmental Cell migration Gastrula biology.organism_classification Fibronectins Cell biology Gastrulation Goosecoid Protein embryonic structures Homeobox Ectopic expression rhoA GTP-Binding Protein 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Development Dyn Development Dyn, 2008, 237 (5), pp.1307-20 |
| Popis: | In the vegetal half of the Xenopus gastrula, cell populations differ with respect to migration on fibronectin substratum. We show that the paired-class homeodomain transcription factors Goosecoid (Gsc), Mix.1, and Siamois (Sia) are involved in the modulation of migration velocity and cell polarity. Mix.1 is expressed in the whole vegetal half and serves as a competence factor that is necessary, but not sufficient, for rapid cell migration and polarization. In the head mesoderm, Gsc and Sia are coexpressed with Mix.1, promoting rapid cell migration and polarization. Ectopic expression of Gsc and Sia in both vegetal and ventral regions often generates paradoxical effects; if a factor activates a certain motility trait in one region, it inhibits it in the other. Migration velocity and cell polarity are regulated independently. Fast and efficiently migrating multipolar cells and slow-moving polarized cells can be obtained by ectopic expression of these transcription factors in different combinations. Developmental Dynamics 237:1307–1320, 2008. © 2008 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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