Angiotensin II Type 1 Receptor Antagonist Downregulates Nonmuscle Myosin Heavy Chains in Spontaneously Hypertensive Rat Aorta
| Autor: | Toshihiro Sakumura, Kozo Fujii, Takahito Yonezawa, Seiji Umemoto, Masunori Matsuzaki, Akihisa Fujii |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Down-Regulation Angiotensin-Converting Enzyme Inhibitors Rats Inbred WKY Muscle Smooth Vascular Muscle hypertrophy Angiotensin Receptor Antagonists Spontaneously hypertensive rat Rats Inbred SHR medicine.artery Internal medicine Myosin Internal Medicine medicine Animals Protein Isoforms Aorta Angiotensin II receptor type 1 Myosin Heavy Chains Chemistry Body Weight Hemodynamics Receptor antagonist Immunohistochemistry Angiotensin II Rats Endocrinology Hypertension MYH7 |
| Zdroj: | Hypertension. 33:975-980 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.33.4.975 |
| Popis: | Abstract —The aim of this study was to clarify the differences between the angiotensin II type 1 (AT 1 ) receptor antagonist and the angiotensin-converting enzyme (ACE) inhibitor on smooth muscle and nonmuscle myosin heavy chain isoforms in aortic smooth muscle cells of Wistar-Kyoto rats and spontaneously hypertensive rats. All 4 myosin heavy chain isoforms are heterogeneously expressed in the smooth muscle cells of the aortic tunica media in 20-week-old rats, and the contractile-type myosin heavy chains are highly expressed in smooth muscle cells of the aortic tunica media compared with the synthetic-type myosin heavy chains. Both the AT 1 receptor antagonist and the ACE inhibitor had the same effects on hemodynamics, smooth muscle cell hypertrophy and proliferation, fibrosis, and vascular remodeling in spontaneously hypertensive rats. However, the AT 1 receptor antagonist had a more potent effect on the downregulation of the synthetic-type myosin heavy chains than the ACE inhibitor in spontaneously hypertensive rat aortic tunica media. In contrast, these effects of the AT 1 receptor antagonist and the ACE inhibitor on hemodynamics, morphology, fibrosis, and expression of myosin heavy chain isoforms in smooth muscle cells of the aortic tunica media were not observed in Wistar-Kyoto rats. Thus, within 6 weeks, the AT 1 receptor antagonist might modulate the cellular composition of myosin heavy chain isoforms in smooth muscle cells more efficiently than the ACE inhibitor, without morphological changes in the spontaneously hypertensive rat aorta. |
| Databáze: | OpenAIRE |
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