In vivo imaging of saccular hydrops in humans reflects sensorineural hearing loss rather than Meniere's disease symptoms

Autor: Maud Medici, Alexandre Krainik, Irène Troprès, Sébastien Schmerber, Michael Eliezer, Georges Dumas, Arnaud Attyé
Přispěvatelé: Service de neuroradiologie [Grenoble], CHU Grenoble, Centre d'Investigation Clinique - Innovation Technologique - INSERM - CHU de Grenoble (CIC-IT Grenoble (CIT803)), CHU Grenoble-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), IRMaGe (IRMaGe ), CHU Grenoble-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Service d'Oto-Rhino-Laryngologie, INSERM U836, équipe 5, Neuroimagerie fonctionnelle et perfusion cérébrale, Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Neuroradiologie & IRM, CHU Grenoble-CHU Grenoble, This work was performed on the IRMaGe platform, member of France Life Imaging network (grant ANR-11-INBS-0006)
Rok vydání: 2017
Předmět:
Male
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging
Contrast Media
0302 clinical medicine
Vertigo
Edema
Prospective Studies
Endolymphatic hydrops
Saccule and Utricle
030223 otorhinolaryngology
Prospective cohort study
ComputingMilieux_MISCELLANEOUS
Neuroradiology
medicine.diagnostic_test
biology
General Medicine
respiratory system
Middle Aged
Magnetic Resonance Imaging
cardiovascular system
Sensorineural hearing loss
Female
Radiology
medicine.symptom
Adult
medicine.medical_specialty
Hearing loss
Hearing Loss
Sensorineural
Sensitivity and Specificity
Diagnosis
Differential
03 medical and health sciences
Imaging
Three-Dimensional
Meglumine
Ophthalmology
otorhinolaryngologic diseases
medicine
Organometallic Compounds
Humans
Radiology
Nuclear Medicine and imaging
cardiovascular diseases
Meniere Disease
Aged
business.industry
Magnetic resonance imaging
biology.organism_classification
medicine.disease
Image Enhancement
Case-Control Studies
business
030217 neurology & neurosurgery
Meniere's disease
Zdroj: European Radiology
European Radiology, Springer Verlag, 2018, 28 (7), pp.2916-2922. ⟨10.1007/s00330-017-5260-7⟩
ISSN: 1432-1084
0938-7994
Popis: A case-controlled imaging study demonstrated that saccular hydrops was specific to Meniere’s disease (MD), but only present in a subset of patients. Here, we compared patients with definite MD, vertigo and sensorineural hearing loss (SNHL) to elucidate the relationship between saccular hydrops and extent of SNHL. In this prospective study, we performed 3D-FLAIR sequences between 4.5 and 5.5 h after contrast media injection in patients with MD (n=20), SNHL (n=20), vertigo (n=20) and 30 healthy subjects. Two radiologists independently graded saccular hydrops. ROC analysis was performed to determine the hearing loss threshold to differentiate patients with saccular hydrops. Saccular hydrops was found in 11 of 20 MD patients, 10 of 20 SNHL patients and in none of the vertigo patients and healthy subjects. In SNHL patients, 45 dB was the threshold above which there was a significant association with saccular hydrops, with sensitivity of 100 % and specificity of 90 %. In MD patients, 40 dB was the threshold above which there was a significant association with saccular hydrops, with sensitivity of 100 % and specificity of 44 %. Our results indicate saccular hydrops as a feature of worse than moderate SNHL rather than MD itself. • MRI helps clinicians to assess patients with isolated low-tone sensorineural hearing loss. • Saccular hydrops correlates with sensorineural hearing loss at levels above 40 dB. • Vertigo patients without sensorineural hearing loss do not have saccular hydrops. • Saccular hydrops is described in patients without clinical diagnosis of Meniere’s disease.
Databáze: OpenAIRE
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