NK1 antagonists based on seven membered lactam scaffolds
| Autor: | Jason Matthew Elliott, Gary G. Chicchi, Ute Gerhard, María Domínguez, Richard Alexander Jelley, Marc M. Kurtz, Alan Wheeldon, Emma J. Carlson, Kwei lan Tsao, Olivier Dirat, A. Brian Jones |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Lactams
Molecular Structure Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Ring (chemistry) Biochemistry Cell Line chemistry.chemical_compound Structure-Activity Relationship chemistry Neurokinin-1 Receptor Antagonists In vivo Drug Discovery Lactam Molecular Medicine Humans Selectivity Molecular Biology |
| Zdroj: | Bioorganicmedicinal chemistry letters. 16(11) |
| ISSN: | 0960-894X |
| Popis: | A new class of high affinity hNK 1 R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures, includes compounds with high affinity, good selectivity, and promising in vivo properties. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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