Evidence that Osteocytes in Autogenous Bone Fragments can Repair Disrupted Canalicular Networks and Connect with Osteocytes in de novo Formed Bone on the Fragment Surface
| Autor: | Furqan A. Shah, Anders Palmquist |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Bone Regeneration Endocrinology Diabetes and Metabolism Early implant healing Bone healing Osteocytes Bone remodeling Extracellular matrix Rats Sprague-Dawley 03 medical and health sciences Endocrinology Osteogenesis Bone cell medicine Animals Orthopedics and Sports Medicine Autogenous bone Original Research Bone Transplantation Chemistry Osteocyte Anatomy Cell biology Rats Sprague dawley 030104 developmental biology medicine.anatomical_structure Microscopy Electron Scanning Implant Scanning electron microscopy |
| Zdroj: | Calcified Tissue International |
| ISSN: | 1432-0827 0171-967X |
| Popis: | Autogenous bone fragments generated during surgery (e.g. implant site preparation) accelerate bone formation by the release of a large variety of growth factors from the extracellular matrix and the cells contained within. Osteocytes, whether viable or apoptotic, within such fragments are able to recruit osteoclasts to a site of bone remodelling. Here, using correlative scanning electron microscopy, we provide compelling evidence that at one week healing in the Sprague Dawley rat tibia, following surgery (and/or the placement of a bone-anchored implant), autogenous bone fragments support bone formation on their surface. Furthermore, osteocytes within the autogenous fragments are frequently able to repair the disrupted canalicular networks and appear to connect with osteocytes (or osteoblastic-osteocytes) in the de novo formed bone on the surface of the fragment. |
| Databáze: | OpenAIRE |
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