Cell Cycle Inhibitory Protein p27 in Human Middle Ear Cholesteatoma
| Autor: | Tadeusz Pawelczyk, Bogusław Mikaszewski, Waldemar Narozny, Alicja Bakowska, Jerzy Kuczkowski |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Epithelium Recurrence otorhinolaryngologic diseases medicine Humans Middle Ear Cholesteatoma Ear canal Child Cholesteatoma Middle Ear business.industry Cholesteatoma Anatomy Middle Aged Cell cycle medicine.disease medicine.anatomical_structure Otorhinolaryngology Case-Control Studies Child Preschool Middle ear Immunohistochemistry Female sense organs Presentation (obstetrics) business Cyclin-Dependent Kinase Inhibitor p27 Ear Canal |
| Zdroj: | ORL. 68:296-301 |
| ISSN: | 1423-0275 0301-1569 |
| DOI: | 10.1159/000094377 |
| Popis: | Aim: To evaluate the immunohistochemical and molecular presentation of protein p27 in cholesteatoma. Methods: 42 cholesteatoma samples and 6 external ear canal skin (EECS) specimens were investigated and analyzed taking into consideration congenital, acquired, recurrent cholesteatoma, and EECS. Results: The expression of p27 was found in 16 (38.1%) out of 42 specimens of cholesteatoma and in 5 (83.3%) out of 6 specimens of EECS. There was a significant difference in p27-positive staining rate between EECS and cholesteatoma epithelium (p < 0.008). The presence of p27 was detected in 10 cases of acquired cholesteatoma, 2 cases of congenital and 3 cases of recurrent cholesteatoma. There was no significant difference between the presence of p27 in cholesteatoma and EECS (p = 0.01). Conclusion: The down-regulation of p27 is a key player in cell cycle control and plays an undefined role in the pathogenesis of all types of cholesteatoma. |
| Databáze: | OpenAIRE |
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