The Importance of Oxidation or Glycosylation of Low-density Lipoproteins in Relation to Platelet Activation

Autor:	C E Moore, S Meraji, V O Skinner, Bruckdorfer Kr
Rok vydání:	1992
Předmět:	Glycosylation Chemistry Hematology General Medicine medicine.disease In vitro chemistry.chemical_compound Biochemistry Diabetes mellitus Plasma lipids medicine Low density lipids (amino acids peptides and proteins) Platelet Platelet activation
Zdroj:	Platelets. 3:155-162
ISSN:	1369-1635 0953-7104
DOI:	10.3109/09537109209013176
Popis:	Low-density lipoproteins (LDL) are thought to influence directly the sensitivity of platelets, but this may only be the case when the LDL are modified by oxidation. In diabetes, LDL are known to be modified by non-enzymatic glycosylation, especially when the blood glucose concentrations are poorly controlled: platelet activation is also concomitantly increased as is the concentration of plasma lipid peroxides. In this study we found that mild oxidation of LDL in vitro is more potent than strongly oxidised LDL in terms of the activation of platelets. Glycosylation of LDL per se has little effect on the aggregation of isolated platelets.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b3b73f36c4b7e04b5267d177ec3035 https://doi.org/10.3109/09537109209013176 Zobrazit plný text záznamu