Amniotic fluid insulin values in women with gestational diabetes as a predictor of emerging diabetes mellitus
| Autor: | Peter Wein, Mary T. Sheedy, S. F. Riley, T. Weerasiri, J. E. Walstab |
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| Rok vydání: | 1993 |
| Předmět: |
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medicine.medical_specialty Amniotic fluid medicine.medical_treatment Birth weight Hypoglycemia Fetal Macrosomia Pregnancy Internal medicine Diabetes mellitus medicine Fetal macrosomia Diabetes Mellitus Birth Weight Humans Insulin Obstetrics business.industry Infant Newborn Obstetrics and Gynecology General Medicine medicine.disease Amniotic Fluid Gestational diabetes Diabetes Gestational Endocrinology Female business Follow-Up Studies Forecasting |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0004-8666 |
| Popis: | Amniotic fluid insulin levels were estimated in 30 women with insulin-dependent diabetes, 216 with gestational diabetes and 27 with normal glucose tolerance. Results were correlated with birth-weight, incidences of fetal macrosomia and neonatal hypoglycaemia, and the risk of the mothers with gestational diabetes developing diabetes mellitus on follow-up. The women with prepregnancy diabetes had significantly higher amniotic fluid insulin values and showed a significant correlation between raised liquor insulin values (> 97th percentile) and hypoglycaemia in the infant (p = 0.039). In the gestational diabetic pregnancies there were highly significant associations between elevated liquor insulin values and macrosomia (p < 0.0045) and birth-weight (p < 0.00004), and a weak correlation with neonatal blood glucose levels (p = 0.042). Women with gestational diabetes who later developed permanent diabetes mellitus had higher mean amniotic fluid insulin levels than those whose glucose tolerance remained normal on follow-up (p < or = 0.0072) and more of them had a level greater than the 97th percentile than those whose glucose tolerance remained normal (odds ratio 6.48, 95% confidence interval 1.51-27.8, p = 0.0094). However a high amniotic fluid insulin level was of less clinical value for detection of women destined to develop diabetes (7 of 25, 28%) than was the need for insulin therapy during pregnancy (18 of 39, 46%). |
| Databáze: | OpenAIRE |
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