Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast
| Autor: | Hyunsung D. Kim, Michael G. Kiflezghi, Ting-I Lee, Ryan M. Kelly, Jared Almazan, Mitchell B. Lee, Siobhan R. Duffy, Shauna A. Hill, Riley Whalen, Feng Y. Yeh, Ellen Huynh, Mitsuhiro Tsuchiya, Bao M.G. Nguyen, Ken Chen, Brian K. Kennedy, Annaiz M. Grimm, Matt Kaeberlein, Joe R. Delaney, Mark A. McCormick, Matthew M. Crane, Ben W. Blue, Jiayi Li, Alison M. Guard, Alexandra Golubeva |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Aging Transition (genetics) Physiology DNA damage Mutant lcsh:R lcsh:Medicine Cell Biology Cell cycle Biology Budding yeast Article Cell size Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Neurology (clinical) Geriatrics and Gerontology Ploidy Gene 030217 neurology & neurosurgery |
| Zdroj: | Translational Medicine of Aging, Vol 3, Iss, Pp 104-108 (2019) |
| ISSN: | 2468-5011 |
| Popis: | An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase replicative lifespan. Upon careful analysis of multiple independently derived haploid and homozygous diploid whi5Δ mutants, we find no effect on lifespan, but we do confirm the reduction in cell size. We suggest that instead of antagonizing lifespan, the elongated G1 phase of the cell cycle during aging may actually play an important role in allowing aged cells time to repair accumulating DNA damage. Keywords: Cell cycle regulation, Replicative aging, Saccharomyces cerevisiae |
| Databáze: | OpenAIRE |
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