A randomized controlled trial of 130 g/day low-carbohydrate diet in type 2 diabetes with poor glycemic control

Autor: Chie Ohmura, Sumiko Makita, Takeshi Ogihara, Chie Hatae, Toyoyoshi Uchida, Hirotaka Watada, Junko Sato, Tomoaki Shimizu, Takeshi Miyatsuka, Nao Hirashima, Hiromasa Goto, Kageumi Takeno, Yoshio Fujitani, Yoshifumi Tamura, Akio Kanazawa, Fuki Ikeda, Satoshi Shimada, Manami Iwaoka, Takehito Watanabe, Kiyoe Kobayashi, Yoshiko Miura, Tomoya Mita, Koji Komiya
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Calorie restricted diet
medicine.medical_specialty
Calorie
Diet
Reducing
Nutritional Sciences
Nutrition Education
030209 endocrinology & metabolism
Type 2 diabetes
Critical Care and Intensive Care Medicine
Body Mass Index
law.invention
Diet
Carbohydrate-Restricted
03 medical and health sciences
0302 clinical medicine
Japan
Patient Education as Topic
Randomized controlled trial
law
Internal medicine
Diet
Diabetic
Weight Loss
medicine
Clinical endpoint
Humans
Medical nutrition therapy
Precision Medicine
Aged
Glycated Hemoglobin
030109 nutrition & dietetics
Nutrition and Dietetics
business.industry
Type 2 Diabetes Mellitus
Middle Aged
Overweight
medicine.disease
Hypoglycemia
eye diseases
Surgery
Diabetes Mellitus
Type 2
Hyperglycemia
Patient Compliance
Female
Energy Intake
business
Follow-Up Studies
Zdroj: Clinical Nutrition. 36:992-1000
ISSN: 0261-5614
0000-1066
DOI: 10.1016/j.clnu.2016.07.003
Popis: Summary Background & aims The usefulness of low-carbohydrate diet (LCD) for Japanese patients with type 2 diabetes mellitus (T2DM) has not been fully investigated. Therefore, we compared the effectiveness and safety of LCD with calorie restricted diet (CRD). Methods This prospective, randomized, open-label, comparative study included 66 T2DM patients with HbA1c >7.5% even after receiving repeated education programs on CRD. They were randomly allocated to either the 130g/day LCD group (n = 33) or CRD group (n = 33). Patients received personal nutrition education of CRD or LCD for 30 min at baseline, 1, 2, 4, and 6 months. Patients of the CRD group were advised to maintain the intake of calories and balance of macronutrients (28× ideal body weight calories per day). Patients of the LCD group were advised to maintain the intake of 130 g/day carbohydrate without other specific restrictions. Several parameters were assessed at baseline and 6 months after each intervention. The primary endpoint was a change in HbA1c level from baseline to the end of the study. Results At baseline, BMI and HbA1c were 26.5 (24.6–30.1) and 8.3 (8.0–9.3), and 26.7 (25.0–30.0) kg/m 2 and 8.0 (7.6–8.9) %, in the CRD and LCD, respectively. At the end of the study, HbA1c decreased by −0.65 (−1.53 to −0.10) % in the LCD group, compared with 0.00 (−0.68 to 0.40) % in the CRD group (p 2 ] exceeded that observed in the CRD group (p = 0.03). Conclusions Our study demonstrated that 6-month 130 g/day LCD reduced HbA1c and BMI in poorly controlled Japanese patients with T2DM. LCD is a potentially useful nutrition therapy for Japanese patients who cannot adhere to CRD. This trial was registered at http://www.umin.ac.jp/english/ (University Hospital Medical Information Network: study ID number 000010663).
Databáze: OpenAIRE
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