Relationships of osteoprotegerin with albuminuria and asymmetric dimethylarginine in essential hypertension: integrating vascular dysfunction
| Autor: | Costas Tsioufis, Kyriakos Dimitriadis, Vasilios Papademetriou, Stella-Maria Kyvelou, Christodoulos Stefanadis, Vanessa Tzamou, Costas Thomopoulos, Alexandros Kasiakogias, Athanasios Aggelis, Dimitri P. Mikhailidis |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Clinical Biochemistry Blood Pressure Arginine Essential hypertension chemistry.chemical_compound Osteoprotegerin Internal medicine Drug Discovery medicine Albuminuria Humans Pharmacology Creatinine business.industry Confounding Albumin Middle Aged medicine.disease Cross-Sectional Studies Blood pressure Endocrinology chemistry Echocardiography Hypertension Molecular Medicine Female Endothelium Vascular medicine.symptom Asymmetric dimethylarginine business |
| Zdroj: | Expert Opinion on Therapeutic Targets. 15:1347-1353 |
| ISSN: | 1744-7631 1472-8222 |
| DOI: | 10.1517/14728222.2011.642868 |
| Popis: | To investigate the inter-relationships of osteoprotegerin (OPG) with albumin to creatinine ratio (ACR) and asymmetric dimethylargine (ADMA) in hypertensive patients.In 198 untreated non-diabetic hypertensive patients [130 males, mean age=51.5 years, office blood pressure (BP)=152/98 mmHg] ACR values and OPG and ADMA levels were determined.Based on the median value of OPG distribution (5.03 pmol/l) patients with high (n=101) compared with those with low OPG values (n=97) had greater 24-h systolic BP (152±5 versus 137±7 mmHg, p0.0001), ACR [25.3 (5-190) versus 17.3 (5-92) mg/g, p=0.003) and ADMA [0.62 (0.58-0.68) versus 0.57 (0.48-0.62) μmol/l, p=0.001), independently of confounding factors. Multiple regression analyses revealed that ADMA (b=0.388, p0.0001), 24-h systolic BP (b=0.228, p=0.01) and ACR (b=0.470, p0.0001) were independent predictors of OPG (R2=0.398, p0.0001).In hypertensive patients, high OPG levels are accompanied by pronounced albuminuria and endothelial dysfunction, as reflected by raised ADMA levels. Furthermore, the independent associations of OPG with ACR and ADMA, suggests a link between OPG and the progression of diffuse hypertensive vascular damage. |
| Databáze: | OpenAIRE |
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