Pre- and Posttransplant IgA Anti-Fab Antibodies to Predict Long-term Kidney Graft Survival
| Autor: | Mohammad Ali Amirzargar, G. Rajabi, Ghasem Solgi, A. A. Amirzargar, Ghodratollah Roshanaei, Mehrdad Hajilooi, Abbas Basiri |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Graft Rejection Male Time Factors Enzyme-Linked Immunosorbent Assay Immunoglobulin Fab Fragments chemistry.chemical_compound Living unrelated donor Living Donors medicine Humans Transplantation Homologous Kidney transplantation Retrospective Studies Transplantation Kidney Creatinine biology business.industry Graft Survival Retrospective cohort study medicine.disease Kidney Transplantation Immunoglobulin A medicine.anatomical_structure chemistry Preoperative Period Immunology biology.protein Female Surgery Graft survival Antibody business Biomarkers |
| Zdroj: | Transplantation Proceedings. 47:1110-1113 |
| ISSN: | 0041-1345 |
| Popis: | Objectives Immunologic factors are reliable markers for allograft monitoring, because of their seminal role in rejection process. One of these factors is the immunoglobulin (Ig)A anti-Fab of the IgG antibody. This study aimed to evaluate the predictive value of pre- and posttransplant levels of this marker for kidney allograft function and survival. Methods Sera samples of 59 living unrelated donor kidney recipients were collected before and after transplantation (days 7, 14, and 30) and investigated for IgA anti-Fab of IgG antibody levels using enzyme-linked immunosorbent assay in relation with allograft outcome. Results Among 59 patients, 15 cases (25%) including 10 with acute rejection and 5 with chronic rejection episodes showed graft failure during a mean of 5 years of follow-up. High posttransplant levels of IgA anti-Fab antibodies were observed more frequently in patients with stable graft function (SGF) compared with patients with graft failure ( P = 2 × 10 −6 ). None of patients with acute or chronic rejection episodes had high levels of IgA anti-Fab antibodies at day 30 posttransplant compared with the SGF group ( P = 10 −6 and P = .01, respectively). In addition, high levels of IgA anti-Fab antibody correlated with lesser concentration of serum creatinine at 1 month posttransplantation ( P = .01). Five-year graft survival was associated with high levels of pre- and posttransplant IgA anti-Fab antibodies ( P = .02 and P = .003, respectively). Conclusions Our findings indicate the protective effect of higher levels of IgA anti-Fab antibodies regarding to kidney allograft outcomes and long-term graft survival. |
| Databáze: | OpenAIRE |
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