Correlation between high-resolution optical coherence tomography (OCT) images and histopathology in an iodoacetic acid-induced model of retinal degeneration in rabbits
| Autor: | Tsuyoshi Agawa, Naoyuki Yamakawa, Keisuke Kimura, Rintaro Tsukahara, Hiroshi Goto, Masahiro Miura, Yasuyuki Yamauchi |
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| Rok vydání: | 2010 |
| Předmět: |
Retinal degeneration
medicine.medical_specialty Time Factors genetic structures Iodoacetic acid High resolution Retina Cellular and Molecular Neuroscience chemistry.chemical_compound Optical coherence tomography Ophthalmology medicine Animals Enzyme Inhibitors medicine.diagnostic_test business.industry Retinal Degeneration Macular disease Anatomy medicine.disease Photoreceptor degeneration eye diseases Sensory Systems Iodoacetic Acid Disease Models Animal medicine.anatomical_structure chemistry Histopathology Rabbits sense organs business Tomography Optical Coherence Photoreceptor Cells Vertebrate |
| Zdroj: | British Journal of Ophthalmology. 95:1157-1160 |
| ISSN: | 0007-1161 |
| DOI: | 10.1136/bjo.2010.186718 |
| Popis: | Background Recent research on macular disease has prompted investigation into the condition of the intersection of the inner and outer segments (IS/OS) and its relationship with retinal photoreceptor abnormalities. Because the relationship between optical coherence tomography (OCT) images and histopathology is unclear, we compared these in an iodoacetic acid (IAA)-induced model of photoreceptor degeneration in rabbits. Methods IAA (20 mg/kg), which is toxic to photoreceptors, was injected into six coloured rabbits. After IAA administration, nine retinas were used for histopathological study: three from rabbits surviving for 1 day and six from rabbits surviving for 4 months. Four healthy rabbit retinas served as controls. OCT images were taken before euthanasia. Results In the controls, OCT images revealed the IS/OS as a clear, straight line. In rabbits surviving for 1 day, the structure of the photoreceptor IS/OS was destroyed and the IS/OS boundary was not visible. In rabbits surviving for 4 months, the IS was still preserved, but the structure of the OS was destroyed or partially disorganised, and the IS/OS was observed as a wavy, broken line on the OCT images. Conclusion The IS/OS on the OCT images reflected the histopathology of the inner and outer segments in a photoreceptor degeneration model. |
| Databáze: | OpenAIRE |
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