Birth Size in Neonates with Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency

Autor: Völkl Tmk, Helmuth G. Dörr, Theresa Penger, Michaela Marx, Andrea Albrecht
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
congenital
hereditary
and neonatal diseases and abnormalities
endocrine system diseases
Endocrinology
Diabetes and Metabolism
Birth weight
genotype
Term newborn
21-hydroxylase deficiency
urologic and male genital diseases
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Cohort Studies
Endocrinology
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Germany
Medicine
Birth Weight
Humans
congenital adrenal hyperplasia
Congenital adrenal hyperplasia
lcsh:RC648-665
Adrenal Hyperplasia
Congenital
business.industry
Obstetrics
Hyperandrogenism
Infant
Newborn
lcsh:RJ1-570
nutritional and metabolic diseases
lcsh:Pediatrics
medicine.disease
Birth size
Body Height
female genital diseases and pregnancy complications
Androgen secretion
Pediatrics
Perinatology and Child Health
Cohort
Classic Congenital Adrenal Hyperplasia
Original Article
Female
business
Zdroj: JCRPE, Vol 11, Iss 1, Pp 41-45 (2019)
Journal of Clinical Research in Pediatric Endocrinology
ISSN: 1308-5735
1308-5727
Popis: Objective: Classic congenital adrenal hyperplasia (CAH) secondary to 21-hydroxylase deficiency is characterized by increased prenatal adrenal androgen secretion. There are a small number of reports in the literature showing higher birth weight and length in CAH newborns. Methods: We analyzed birth weight and length data of 116 German newborns (48 boys, 68 girls) with classic CAH who were born during the period from 1990 to 2017. All children have been followed or are currently treated as outpatients in our clinic. All children were born at term. The mothers were healthy and their pregnancies were uneventful. The diagnosis of CAH was confirmed by molecular analyses of the CYP21A2 gene. Birth data were calculated as standard deviation (SD) scores according to German reference values. Results: Weight and length in male CAH newborns (mean ± SD) (3601±576 g; 52.4±2.85 cm) were significantly higher than in female CAH newborns (3347±442 g; 51.2±2.55 cm), but male-female differences in the CAH cohort were lost when the data were converted into SD scores. The birth sizes of the CAH newborns did not differ from the reference group. The birth sizes also did not differ between the different CAH genotypes. Maternal age, mode of delivery and maternal parity had no influence on birth size. Conclusion: Our data show that prenatal hyperandrogenism does not affect fetal growth.
Databáze: OpenAIRE
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