Auditory verbal hallucinations are related to cortical thinning in the left middle temporal gyrus of patients with schizophrenia
| Autor: | D Zhang, H Yan, Tianzi Jiang, Shejuan Xie, Yunchun Chen, P Li, H Wang, Bing Liu, Jiong Li, Lin Lu, Luxian Lv, Yue Cui, Haisan Zhang, Darren M. Lipnicki, J Yan, Ming Song |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male China medicine.medical_specialty Hallucinations Middle temporal gyrus Cortical thinning Audiology Left middle temporal gyrus Young Adult 03 medical and health sciences 0302 clinical medicine Neuroimaging Abnormally thin medicine Humans In patient Psychiatry Applied Psychology medicine.diagnostic_test Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Temporal Lobe 030227 psychiatry Psychiatry and Mental health Schizophrenia Case-Control Studies Female Psychology 030217 neurology & neurosurgery |
| Zdroj: | Psychological Medicine. 48:115-122 |
| ISSN: | 1469-8978 0033-2917 |
| DOI: | 10.1017/s0033291717001520 |
| Popis: | BackgroundAuditory verbal hallucinations (AVHs) are one of the most common and severe symptoms of schizophrenia, but the neuroanatomical abnormalities underlying AVHs are not well understood. The present study aims to investigate whether AVHs are associated with cortical thinning.MethodsParticipants were schizophrenia patients from four centers across China, 115 with AVHs and 93 without AVHs, as well as 261 healthy controls. All received 3 T T1-weighted brain scans, and whole brain vertex-wise cortical thickness was compared across groups. Correlations between AVH severity and cortical thickness were also determined.ResultsThe left middle part of the middle temporal gyrus (MTG) was significantly thinner in schizophrenia patients with AVHs than in patients without AVHs and healthy controls. Inferences were made using a false discovery rate approach with a threshold at p < 0.05. Left MTG thickness did not differ between patients without AVHs and controls. These results were replicated by a meta-analysis showing them to be consistent across the four centers. Cortical thickness of the left MTG was also found to be inversely correlated with hallucination severity across all schizophrenia patients.ConclusionThe results of this multi-center study suggest that an abnormally thin left MTG could be involved in the pathogenesis of AVHs in schizophrenia. |
| Databáze: | OpenAIRE |
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