Bioactive glass S53P4 as bone graft substitute in treatment of osteomyelitis
| Autor: | Mikko O. Kirjavainen, Jari Salo, E. Gullichsen, Jyrki Kankare, Nina Lindfors, Pekka Hyvönen, M. Nyyssönen |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Staphylococcus aureus Histology Bone substitute Adolescent Physiology Endocrinology Diabetes and Metabolism Dentistry medicine.disease_cause law.invention law medicine Humans Bone formation Antibacterial agent Aged Aged 80 and over Postoperative Care Bioactive glass S53P4 Bone Transplantation Tibia business.industry Osteomyelitis Mycobacterium tuberculosis Middle Aged medicine.disease Spine Surgery Radiography Bioactive glass Bone Substitutes Female Glass Osteitis business |
| Zdroj: | Bone. 47(2) |
| ISSN: | 1873-2763 |
| Popis: | Bioactive glass (BAG)-S53P4 is an osteoconductive bone substitute with proven antibacterial and bone bonding properties. In a multicentre study 11 patients with verified chronic osteomyelitis in the lower extremity and the spine were treated with BAG-S53P4 as a bone substitute. The cavitary bone defect and the surrounding of a spinal implant were filled with BAG-S53P4. The most common pathogen causing the infection was Staphylococcus aureus. The mean follow-up was 24 months (range 10-38). BAG-S53P4 was well tolerated. Nine patients healed without complications. One patient who achieved good bone formation sustained a superficial wound infection due to vascular problems in the muscle flap, and one patient had an infection due to a deep haematoma. This study shows that BAG-S53P4 is a good and well-tolerated bone substitute, and can be used in treatment of osteomyelitis with good primary results. |
| Databáze: | OpenAIRE |
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