Mechanism of semen liquefaction and its potential for a novel non-hormonal contraception†
| Autor: | Wipawee Winuthayanon, Prashanth Anamthathmakula |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Proteases endocrine system contraceptive Ejaculation Semen semen liquefaction Biology Male infertility Andrology 03 medical and health sciences fluids and secretions 0302 clinical medicine medicine prostate-specific antigen Animals Humans Sperm motility Infertility Male fertility 030219 obstetrics & reproductive medicine urogenital system Contraceptive Agents Male Liquefaction Cell Biology General Medicine Contraceptive Special Issue medicine.disease AcademicSubjects/SCI01070 Sperm semenogelins Prostate-specific antigen 030104 developmental biology Reproductive Medicine kallikrein-related peptidase Proteolysis Sperm Motility AcademicSubjects/MED00773 |
| Zdroj: | Biology of Reproduction |
| ISSN: | 1529-7268 0006-3363 |
| Popis: | Semen liquefaction is a proteolytic process where a gel-like ejaculated semen becomes watery due to the enzymatic activity of prostate-derived serine proteases in the female reproductive tract. The liquefaction process is crucial for the sperm to gain their motility and successful transport to the fertilization site in Fallopian tubes (or oviducts in animals). Hyperviscous semen or failure in liquefaction is one of the causes of male infertility. Therefore, the biochemical inhibition of serine proteases in the female reproductive tract after ejaculation is a prime target for novel contraceptive development. Herein, we will discuss protein components in the ejaculates responsible for semen liquefaction and any developments of contraceptive methods in the past that involve the liquefaction process. We propose inhibition of semen liquefaction has the potential to be developed as a non-hormonal contraceptive method. |
| Databáze: | OpenAIRE |
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