Physical and chemical stability of cytarabine in polypropylene syringes
| Autor: | Myriam Razgallah Khrouf, Chema Drira, Mohamed Ali Soussi, Wiem Ben Ayed, Hanen Ouesleti, Ines Fradi, Fathi Safta, Besma Hamdene |
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| Rok vydání: | 2020 |
| Předmět: |
Antimetabolites
Antineoplastic Drug Compounding Drug Storage Polypropylenes 030226 pharmacology & pharmacy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Stability Limit of Detection medicine Pharmacology (medical) Chromatography High Pressure Liquid Polypropylene Chromatography business.industry Syringes Cytarabine Temperature Reproducibility of Results Pharmaceutical Solutions Oncology chemistry 030220 oncology & carcinogenesis Chemical stability Glass Saline Solution business medicine.drug |
| Zdroj: | Journal of Oncology Pharmacy Practice. 27:827-833 |
| ISSN: | 1477-092X 1078-1552 |
| Popis: | Background Cytarabine is widely used to treat leukemia and lymphoma. Currently, Cyrabol®, powder for injection, is one of the specialties marketed in Tunisia. However, no stability data when diluted with 0.9% NaCl are available. The aim of this study is to evaluate the physical and chemical stability of cytarabine (Cyrabol®) solution after dilution in 0.9% NaCl (1 mg/mL, 5 mg/mL and 10 mg/mL) in polypropylene syringes under different storage conditions. Methods Cytarabine solutions (1 mg/mL, 5 mg/mL and 10 mg/mL) in 0.9% NaCl were prepared in polypropylene syringes and stored for 28 days under different conditions. Cytarabine preparations in glass containers were prepared as a control to detect any adsorption. Chemical stability was assessed by a stability-indicating high-performance liquid chromatography method. The stability-indicating capacity of the method was proved by forced degradation tests. Linearity, precision and limit of detection and quantification were performed according to the International Conference on Harmonisation recommendations. Physical stability was checked by visual inspection. Results The method was proven to be a validated stability-indicating assay. At 2–8°C, all tested solutions were chemically stable for 28 days. However, at 25°C, the main degradation product gradually increased during the study and the chemical stability of 1 mg/mL, 5 mg/mL and 10 mg/mL solutions was 14 days, 8 days and 5 days, respectively. Similar results were observed in the glass containers. Conclusion The highest physical and chemical stability of cytarabine diluted in 0.9% NaCl in polypropylene syringes was observed at 2–8°C. At 25°C, better stability was found in the 1 mg/mL solution compared with those at higher concentrations (5 mg/mL and 10 mg/mL). |
| Databáze: | OpenAIRE |
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