Antiepileptic effect of olanzapine in epilepsy patients with atypical depressive comorbidity
| Autor: | Xi Zhu, Lei Chen, Peter Wolf, Anjiao Peng, Xiangmiao Qiu, Bianca de Lemos Zingano, Jianan Duan, Shixu He |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Olanzapine
Adult Pediatrics medicine.medical_specialty olanzapine Antidepressive Agents/therapeutic use Epilepsy Benzodiazepines Young Adult Benzodiazepines/therapeutic use interictal dysphoric disorder medicine Humans Depressive Disorder/complications Bipolar disorder Atypical depression Epilepsy/complications Depression (differential diagnoses) bipolar disorder Depressive Disorder business.industry Anticonvulsants/therapeutic use General Medicine medicine.disease Antidepressive Agents Mood Treatment Outcome Neurology depression Antidepressant epilepsy Anticonvulsants Female Neurology (clinical) medicine.symptom business Interictal dysphoric disorder medicine.drug |
| Zdroj: | Qiu, X, Zingano, B, He, S, Zhu, X, Peng, A, Duan, J, Wolf, P & Chen, L 2018, ' Antiepileptic effect of olanzapine in epilepsy patients with atypical depressive comorbidity ', Epileptic Disorders, vol. 20, no. 3, pp. 225-231 . https://doi.org/10.1684/epd.2018.0977 |
| ISSN: | 1950-6945 |
| DOI: | 10.1684/epd.2018.0977 |
| Popis: | Depression is relatively common among patients with epilepsy, but often with predominant atypical symptoms. Some antiepileptic drugs show positive psychotropic effects, but these are not always sufficient to stabilize mood in epilepsy patients. Antidepressants are recommended to treat atypical depression but are not always effective and present a certain risk of seizure provocation. Thus, new treatment options are welcome. Here, we describe three cases of refractory epilepsy with atypical depression in which olanzapine, contrary to its earlier reported proconvulsant effect, showed excellent antidepressant action and resulted in seizure control. Possible mechanisms of this action are discussed. |
| Databáze: | OpenAIRE |
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