Relationship between the paraoxonase 1 (PON1) M55L and Q192R polymorphisms and lymphohaematopoietic cancers in a Greek agricultural population
| Autor: | Pavlina Almpanidou, Christos Hadjichristodoulou, Michalis Koureas, Alexandra Kalogeraki, Georgios M. Hadjigeorgiou, Maria Kokouva, D.S. Kyriakou, Efthimios Dardiotis |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Genotype Lymphoma Population Toxicology Polymorphism Single Nucleotide Polymorphism (computer science) Humans Medicine Medical history Family history education Aged Genetics education.field_of_study Greece biology Aryldialkylphosphatase business.industry Confounding Pesticide Residues Paraoxonase Agriculture Middle Aged PON1 Occupational Diseases Logistic Models Case-Control Studies Hematologic Neoplasms biology.protein Female business Demography |
| Zdroj: | Toxicology. 307:12-16 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/j.tox.2012.07.003 |
| Popis: | a b s t r a c t The aim of this study was to investigate the association between Paraoxonase 1 (PON1) gene polymor- phisms (M55L and Q192R) and lymphohaematopoietic cancers (LHC) in an agricultural region of Greece. A hospital-based case-control study was conducted. A structured questionnaire including information on demographics, residence, occupation, agricultural practices, pesticide exposure, family history, smoking, alcohol consumption and medical history, was used. Genotyping of 316 cases of LHC and 351 healthy controls by using standard laboratory methods was performed. To control for confounders, Binary and Multinomial Logistic Regression analyses were used. Possession of QQ genotype or presence of the Q allele were associated with increased risk of devel- oping LHC (OR 1.94, 95% CI 1.42-2.66 and OR 1.72, 95% CI 1.33-2.23 respectively). The QQ genotype in the recessive model was independently associated with LHC (OR 1.92, 95% CI 1.40-2.65), leukaemia (OR 1.99, 95% CI 1.13-3.49), lymphoma (OR 2.17, 95% CI 1.21-3.90) and plasmacell disease (OR 1.92, 95% CI 1.40-2.65) even after controlling for age, sex, pesticide exposure, smoking and family history (cancers, LHC and immunological disorders) as confounders. Possession of QQ genotype was found to have a stronger association with LHC in the high and medium pesticide exposed groups(OR 2.15, 95% CI 1.35-3.40, P-value 0.001 and OR 2.25, 95% CI 1.21-4.19, P-value 0.010 respectively), compared with the Low/No exposed group where the association was not statistically significant (OR 1.51, 95% CI 0.76-3.00, P-value 0.224). We found no association between M55L polymorphism and LHC. PON1 polymorphisms may influence the risk for LHC in our agricultural area. The results encourage further investigation on the PON1 polymorphisms and their importance on the individual's susceptibility especially when exposure to pesticides occurs. © 2012 Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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