Enteral nutrition supplemented with L-glutamine in patients with systemic inflammatory response syndrome due to pulmonary infection
| Autor: | Paulo Roberto Leitão de Vasconcelos, Marcio Wilker Soares Campelo, Sergio Botelho Guimarães, Ana Augusta Monteiro Cavalcante, José Huygens Parente Garcia, Marcelo Pinho Pessoa de Vasconcelos, Camila Marques Ferreira |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Glutamine Biology Lipid peroxidation Sepsis chemistry.chemical_compound Enteral Nutrition Double-Blind Method Intensive care Internal medicine medicine Humans Urea Lymphocyte Count Lymphocytes Respiratory Tract Infections Aged Aged 80 and over Nutrition and Dietetics Caseins Calcium caseinate Glutathione Middle Aged medicine.disease Systemic Inflammatory Response Syndrome Systemic inflammatory response syndrome Endocrinology Parenteral nutrition chemistry Immunology Dietary Supplements biology.protein Female Lipid Peroxidation |
| Zdroj: | Nutrition (Burbank, Los Angeles County, Calif.). 28(4) |
| ISSN: | 1873-1244 |
| Popis: | To evaluate the effect of enteral nutrition (EN) supplemented with l-glutamine on glycolytic parameters, inflammation, immune function, and oxidative stress in moderately ill intensive care patients with sepsis.Thirty patients received EN. Fifteen patients received EN supplemented with glutamine (30 g; GLN group) for 2 d followed by EN supplemented with calcium caseinate (30 g, CAS group), also over 2 d. The other 15 patients received EN with calcium caseinate (30 g; CAS group) for 2 d followed by EN with glutamine (30 g; GLN group), also over 2 days. One washout day with only EN was provided between every 2-d period of EN plus supplementation to all patients. Blood samples were taken before and after supplementation.There were no changes in glycolytic parameters in either group. Leukocytes decreased in the two groups (from 13 650 to 11 500 in the CAS group, P = 0.019; from 12.850 to 11.000 in the GLN group, P = 0.046). Lymphocytes increased in the GLN group (from 954 to 1916, P0.0001) and were more numerous after glutamine supplementation (from 1916 to 1085, P0.0001, GLN versus CAS). No significant changes were observed in interleukin levels, but urea levels were higher in the GLN compared with the CAS group (50.0-47.0, P = 0.030). Glutathione plasma concentrations did not differ significantly between the groups. No significant changes were observed in the plasma glutamine and glutamate concentrations.The EN supplemented with glutamine increased the lymphocyte count and helped to decrease lipid peroxidation but presented no effect on the antioxidant glutathione capacity and on cytokine concentrations or glycolytic parameters. |
| Databáze: | OpenAIRE |
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