Fibrin clot structure - pro-fibrinolytic effect of oral contraceptives in apparently healthy women
| Autor: | Ulrich Winkler, Johannes Jakobsen Sidelmann, Andrea H. Krug, Jørgen Jespersen, Jørgen Gram, Cornelis Kluft |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
alpha-2-Antiplasmin/metabolism Time Factors Protein Conformation medicine.medical_treatment Clot lysis Peptide Hydrolases/blood 030204 cardiovascular system & hematology Fibrinogen Plasminogen/metabolism Tissue plasminogen activator 0302 clinical medicine Fibrinolysin education.field_of_study biology Fibrinolysis Thrombin Hematology Fibrinolysis/drug effects Fibrin/chemistry Europe Contraceptives Oral Hormonal/administration & dosage Coagulation Female Fibrin Fibrinogen Degradation Products/metabolism medicine.drug Adult medicine.medical_specialty Adolescent Drug Compounding Population Antithrombin III Fibrin Drug Administration Schedule Contraceptives Oral Hormonal Fibrin structure Fibrin Fibrinogen Degradation Products 03 medical and health sciences Fibrinolysin/metabolism Young Adult Internal medicine medicine Humans education Blood Coagulation alpha-2-Antiplasmin Thrombin/metabolism Oral contraceptives business.industry Plasminogen 030104 developmental biology Endocrinology Blood Coagulation/drug effects Immunology biology.protein business Biomarkers/blood Biomarkers Peptide Hydrolases |
| Zdroj: | Sidelmann, J J, Kluft, C, Krug, A H, Winkler, U, Jespersen, J & Gram, J B 2017, ' Fibrin clot structure-pro-fibrinolytic effect of oral contraceptives in apparently healthy women ', Thrombosis and Haemostasis, vol. 117, no. 4, pp. 700-705 . https://doi.org/10.1160/TH16-10-0748 |
| ISSN: | 2567-689X |
| DOI: | 10.1160/TH16-10-0748 |
| Popis: | SummaryFibrin metabolism is influenced by many factors. The velocity of fibrin formation, genetic polymorphisms, fibrinolytic features and the structure of the fibrin clot are determinants of fibrin turnover. Oral contraceptives (OCs) have significant impact on the haemostatic system, by increasing the concentration of coagulation factors, plasminogen and tissue plasminogen activator activity, and decreasing the concentration of haemostatic inhibitors. The present study addresses the influence of OCs on fibrin structure and fibrin metabolism. The study included 70 women treated with seven different OC-formulations. Blood was collected at baseline and after six months of OCs. The plasma concentration of fibrinogen, thrombin-antithrombin complex (TAT), plasminogen, plasmin-antiplasmin complex (PAP), D-Dimer and thrombin generation measures were determined. Fibrin structure measures and fibrin clot lysis not affected by the plasma concentration of plasminogen activators and inhibitors were determined. OCs increased the concentration of fibrinogen, TAT, plasminogen, PAP and D-dimer significantly and affected measures of thrombin generation (p |
| Databáze: | OpenAIRE |
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