Prognostic Significance of Extracellular Matrix Metalloproteinase Inducer and Matrix Metalloproteinase 2 in Epithelial Ovarian Cancer
| Autor: | Markku Tammi, Veli-Matti Kosma, Sari M. Sillanpää, Maarit Anttila, Reijo Sironen, Ulla Puistola, K. Suhonen, Kirsi Hämäläinen, Taina Turpeenniemi-Hujanen, Seppo Saarikoski |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Matrix metalloproteinase Cystadenocarcinoma Mucinous Extracellular matrix Cystadenoma Mucinous Humans Medicine Single-Blind Method Inducer Epithelial ovarian cancer Hyaluronic Acid Aged Aged 80 and over Ovarian Neoplasms Metalloproteinase business.industry Carcinoma Cell Membrane Cystadenoma Serous General Medicine Middle Aged Prognosis medicine.disease Cystadenocarcinoma Serous Neoplasm Proteins Serous fluid Cancer cell Basigin Cancer research Matrix Metalloproteinase 2 Female Stromal Cells business Ovarian cancer Carcinoma Endometrioid Adenocarcinoma Clear Cell Follow-Up Studies |
| Zdroj: | Tumor Biology. 28:280-289 |
| ISSN: | 1423-0380 1010-4283 |
| DOI: | 10.1159/000110426 |
| Popis: | We investigated the prognostic significance of extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase 2 (MMP-2) in epithelial ovarian cancer as well as their relation to hyaluronan (HA) expression.The expression of EMMPRIN and MMP-2 was analyzed immunohistochemically in 295 primary epithelial ovarian cancer patients and 67 metastases.A low membranous EMMPRIN expression was detected more often in serous tumors than in other types (p0.0005) and it was associated with tumors of advanced stage (p = 0.012) or with a large primary residual (p = 0.011). A low expression of MMP-2 in cancer cells was associated with a high histologic grade (grade 3) of the tumor (p = 0.005) and endometrioid type of tumors (p0.0005). Stromal MMP-2 expression was significantly associated with strong stromal HA expression (p = 0.002, r = 0.187). In univariate analysis, 10-year disease-related (DRS) and recurrence-free survivals were significantly better when MMP-2 expression in cancer cells was high (p = 0.0057 and p = 0.0467, respectively). DRS was also better when membranous EMMPRIN expression was high (p = 0.013). In multivariate analysis, strong MMP-2 in cancer cells (RR = 1.48, CI = 1.07-2.04, p = 0.017) indicated favorable DRS.Our results show that EMMPRIN and MMP-2 in cancer cells are significant indicators of a favorable prognosis of epithelial ovarian cancer. |
| Databáze: | OpenAIRE |
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