Peptides in BioNMR Research
| Autor: | Kathryn K Oi, Matthias Schuster, Oliver Zerbe, Kerstin Moehle, Christian R. Baumann, Erich Michel |
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| Přispěvatelé: | University of Zurich, Zerbe, Oliver |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
10120 Department of Chemistry
Allosteric modulator Adrenergic receptor Peptide 1600 General Chemistry repeat protein nmr chemistry.chemical_compound Biosynthesis Receptors Adrenergic alpha-1 antibiotic 540 Chemistry Humans Receptor QD1-999 chemistry.chemical_classification lpt General Medicine General Chemistry Folding (chemistry) Chemistry chemistry Heteronuclear molecule Biophysics Bacterial outer membrane Peptides gpcrs |
| Zdroj: | CHIMIA, Vol 75, Iss 6, Pp 505-507 (2021) |
| Popis: | Heteronuclear NMR in combination with isotope labelling is used to study folding of polypeptides induced by metals in the case of metallothioneins, binding of the peptidic allosteric modulator ?-TIA to the human G-protein coupled ?1b adrenergic receptor, the development of therapeutic drugs that interfere with the biosynthesis of the outer membrane of Gram-negative bacteria, and a system in which protein assembly is induced upon peptide addition. NMR in these cases is used to derive precise structural data and to study the dynamics. |
| Databáze: | OpenAIRE |
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