Role of gut microbiota via the gut-liver-brain axis in digestive diseases
| Autor: | Jianhong Ding, Yanxia Hu, Jun Lou, Qian Du, Jingyu Xu, Rui Xie, Zhe Jin, Qiushi Liao, Weixi Shan, Xiaoxu Yang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Alcoholic liver disease
Gut-liver axis Central nervous system Review Gut microbiota Gut flora digestive system Inflammatory bowel disease Enteric Nervous System Irritable Bowel Syndrome 03 medical and health sciences 0302 clinical medicine medicine Humans Herbaceous medications Irritable bowel syndrome biology business.industry digestive oral and skin physiology Fatty liver Gastroenterology Brain General Medicine Microbiota-gut-brain axis biology.organism_classification medicine.disease Gastrointestinal Microbiome Autonomic nervous system medicine.anatomical_structure Liver 030220 oncology & carcinogenesis Immunology Digestive diseases 030211 gastroenterology & hepatology Enteric nervous system business |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 1007-9327 |
| Popis: | The gut-brain axis is a bidirectional information interaction system between the central nervous system (CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the enteric nervous system, the autonomic nervous system, and the neuroendocrine and neuroimmunity of the CNS, which is called the microbiota-gut-brain axis. Due to the close anatomical and functional interaction of the gut-liver axis, the microbiota-gut-liver-brain axis has attracted increased attention in recent years. The microbiota-gut-liver-brain axis mediates the occurrence and development of many diseases, and it offers a direction for the research of disease treatment. In this review, we mainly discuss the role of the gut microbiota in the irritable bowel syndrome, inflammatory bowel disease, functional dyspepsia, non-alcoholic fatty liver disease, alcoholic liver disease, cirrhosis and hepatic encephalopathy via the gut-liver-brain axis, and the focus is to clarify the potential mechanisms and treatment of digestive diseases based on the further understanding of the microbiota-gut- liver-brain axis. |
| Databáze: | OpenAIRE |
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