Ion flow in cochlear hair cells and the regulation of hearing sensitivity
| Autor: | Robert Patuzzi |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Endocochlear potential Audiology Membrane Potentials Hearing Hair Cells Auditory otorhinolaryngologic diseases medicine Animals Humans Autoregulation Ion transporter Cochlea Membrane potential Ion Transport biology Membrane transport protein Chemistry Membrane Transport Proteins Sensory Systems Transport protein medicine.anatomical_structure biology.protein Biophysics Calcium sense organs Hair cell |
| Zdroj: | Hearing Research. 280:3-20 |
| ISSN: | 0378-5955 |
| DOI: | 10.1016/j.heares.2011.04.006 |
| Popis: | This paper discusses how ion transport proteins in the hair cells of the mammalian cochlea work to produce a sensitive but stable hearing organ. The transport proteins in the inner and outer hair cells are summarized (including their current voltage characteristics), and the roles of these proteins in determining intracellular Ca(2+), membrane potential, and ultimately cochlear sensitivity are discussed. The paper also discusses the role of the Ca(2+) sequestration sacs in outer hair cells in the autoregulation of hair cell membrane potential and cochlear gain, and how the underdamped control of Ca(2+) within these sacs may produce the observed slow oscillations in cochlear sensitivity and otoacoustic emissions after cochlear perturbations, including perilymphatic perfusions and prolonged low-frequency tones. The relative insensitivity of cochlear gain to short-term changes in the endocochlear potential is also discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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