Metformin as additional therapy in adolescents with poorly controlled type 1 diabetes: randomised placebo-controlled trial with aspects on insulin sensitivity
| Autor: | Stefan Särnblad, Marianne Kroon, Jan Åman |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Placebo-controlled study Placebo law.invention Placebos Endocrinology Randomized controlled trial Double-Blind Method law Diabetes mellitus Internal medicine medicine Humans Hypoglycemic Agents Insulin Insulin-Like Growth Factor I Glycated Hemoglobin Type 1 diabetes business.industry General Medicine medicine.disease Metformin Clinical trial Insulin-Like Growth Factor Binding Protein 1 Diabetes Mellitus Type 1 Body Composition Glucose Clamp Technique Patient Compliance Female business medicine.drug |
| Zdroj: | European journal of endocrinology. 149(4) |
| ISSN: | 0804-4643 |
| Popis: | OBJECTIVE: Metabolic control often deteriorates during puberty in children with type 1 diabetes. The aim of the present study was to investigate whether addition of metformin for 3 Months improves metabolic control and insulin sensitivity. DESIGN: Twenty-six of 30 randomised adolescents with type 1 diabetes (18 females, eight males) completed a double-blind placebo-controlled trial. Their mean age was 16.9+/-1.6 (s.d.) Years, mean glycated haemoglobin (HbA(1c)) 9.5+/-1.1% and daily insulin dosage 1.2+/-0.3 U/kg. The participants were randomised to receive oral metformin or placebo for 3 Months. HbA(1c) was measured Monthly, and peripheral insulin sensitivity was assessed by a euglycaemic hyperinsulinaemic clamp at baseline and at the end of the study. RESULTS: HbA(1c) decreased significantly in the group treated with metformin, from 9.6 to 8.7% (P |
| Databáze: | OpenAIRE |
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