Amyloid deposition detected with florbetapir F 18 (18F-AV-45) is related to lower episodic memory performance in clinically normal older individuals
| Autor: | Mark A. Mintun, Adam S. Fleisher, Eric M. Reiman, Keith A. Johnson, Daniel Skovronsky, Ming Lu, Christopher M. Clark, Matthew Flitter, Michael Grundman, Mat D. Davis, P. Murali Doraiswamy, Michael J. Pontecorvo, Abhinay D. Joshi, Marwan N. Sabbagh, Reisa A. Sperling, Alan Carpenter, Carl H. Sadowsky |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Fluorine Radioisotopes Aging medicine.medical_specialty Pathology Amyloid Memory Episodic Neuropsychological Tests Article Internal medicine medicine Humans Cognitive decline Episodic memory Aged Aged 80 and over Cerebral Cortex Memory Disorders Amyloid beta-Peptides Aniline Compounds medicine.diagnostic_test General Neuroscience Cognition Middle Aged Cognitive test Amyloid deposition medicine.anatomical_structure Cerebral cortex Positron emission tomography Positron-Emission Tomography Mental Recall Cardiology Ethylene Glycols Female Neurology (clinical) Radiopharmaceuticals Geriatrics and Gerontology Psychology Developmental Biology |
| Zdroj: | Neurobiology of Aging. 34:822-831 |
| ISSN: | 0197-4580 |
| Popis: | The objective of this study was to evaluate the relationship of amyloid burden, as assessed by florbetapir F 18 (18F-AV-45) amyloid positron emission tomography, and cognition in healthy older control (HC) subjects. Seventy-eight HC subjects were assessed with a brief cognitive test battery and positron emission tomography (PET) imaging with 18F-AV-45. A standard uptake value ratio was computed for mean data from 6 cortical regions using a whole cerebellum reference region. Scans were also visually rated as amyloid positive or amyloid negative by 3 readers. Higher standard uptake value ratio correlated with lower immediate memory (r = −0.33; p = 0.003) and delayed recall scores (r = −0.25; p = 0.027). Performance on immediate recall was also lower in the visually rated amyloid positive compared with amyloid negative HC (p = 0.04), with a similar trend observed in delayed recall (p = 0.06). These findings support the hypothesis that higher amyloid burden is associated with lower memory performance among clinically normal older subjects. Longitudinal follow-up is ongoing to determine whether 18F-AV-45 may also predict subsequent cognitive decline. |
| Databáze: | OpenAIRE |
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