Cyclic adenosine 3',5'-monophosphate regulation of the bacteriophage T6/colicin K receptor in Escherichia coli
| Autor: | T Melton, S S Dills, E M Alderman, W J Dobrogosz |
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| Rok vydání: | 1979 |
| Předmět: |
Transcription
Genetic Receptors Drug Mutant Colicins Biology medicine.disease_cause Microbiology Receptors Cyclic AMP Bacteriophage Bacterial Proteins medicine Cyclic AMP Escherichia coli Receptor Molecular Biology Gel electrophoresis biology.organism_classification Adenosine Molecular biology Biochemistry Colicin Mutation Receptors Virus Bacterial outer membrane medicine.drug Research Article |
| Zdroj: | Journal of bacteriology. 140(2) |
| ISSN: | 0021-9193 |
| Popis: | Mutant strains of Escherichia coli unable to synthesize cyclic adenosine 3',5'-monophosphate (cAMP) or the cyclic adenosine monophosphate receptor protein (CRP) were more resistant than wild-type cells to infection by bacteriophage T6. This resistance was found to be associated with the decreased production of specific T6 receptor protein (also the colicin K receptor) located in the outer membrane protein fraction of these cells. Transcription of this particular outer membrane protein was regulated by the cAMP-CRP complex. A novel affinity technique coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis was used in these investigations. |
| Databáze: | OpenAIRE |
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