Functional association between proximal and distal gastric motility during fasting and duodenal nutrient stimulation in humans
| Autor: | Nam Q. Nguyen, Robert J. Fraser, Richard H. Holloway, Laura K. Bryant |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Duodenum Manometry Physiology Gastric motility Stimulation Biology Gastroenterology Eating Dietary Sucrose Internal medicine Healthy volunteers Pyloric Antrum medicine Humans Gastric Fundus Motor activity Antrum Food Formulated Meal Endocrine and Autonomic Systems Stomach digestive oral and skin physiology Cardia Fasting Pylorus Barostat digestive system diseases medicine.anatomical_structure Gastric Emptying Female Muscle Contraction |
| Zdroj: | Neurogastroenterology & Motility. 19:638-645 |
| ISSN: | 1365-2982 1350-1925 |
| DOI: | 10.1111/j.1365-2982.2007.00919.x |
| Popis: | A functional integration exists between proximal and distal gastric motor activity in dogs but has not been demonstrated in humans. To determine the relationship between proximal and distal gastric motor activity in humans. Concurrent proximal (barostat) and distal (antro-pyloro-duodenal (APD) manometry) gastric motility were recorded in 10 healthy volunteers (28 +/- 3 years) during (i) fasting and (ii) two 60-min duodenal infusions of Ensure((R)) (1 and 2 kcal min(-1)) in random order. Proximal and APD motor activity and the association between fundic and propagated antral waves (PAWs) were determined. During fasting, 32% of fundic waves (FWs) were followed by a PAW. In a dose-dependent fashion, duodenal nutrients (i) increased proximal gastric volume, (ii) reduced fundic and antral wave (total and propagated) activity, and (iii) increased pyloric contractions. The proportion of FWs followed by a distal PAW was similar between both infusions and did not differ from fasting. During nutrient infusion, nearly all PAWs were antegrade, propagated over a shorter distance and less likely to traverse the pylorus, compared with fasting. In humans, a functional association exists between proximal and distal gastric motility during fasting and duodenal nutrient stimulation. This may have a role in optimizing intra-gastric meal distribution. |
| Databáze: | OpenAIRE |
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