Plasma aldosterone levels and aldosterone-to-renin ratios are associated with endothelial dysfunction in young to middle-aged subjects
| Autor: | Henri Wallaschofski, Martin Reincke, Henry Völzke, Klaus Empen, U. Lendeckel, Matthias Nauck, Rainer Rettig, Jan Lüdemann, Anke Hannemann, Marcus Dörr, Stephan B. Felix, Marcello Ricardo Paulista Markus |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty Brachial Artery Population Reference range Risk Assessment Renin-Angiotensin System chemistry.chemical_compound Risk Factors Germany Internal medicine Renin Odds Ratio Humans Medicine Longitudinal Studies education Aldosterone education.field_of_study Chi-Square Distribution Aldosterone-to-renin ratio business.industry Age Factors Odds ratio Middle Aged Atherosclerosis Confidence interval Up-Regulation Vasodilation Logistic Models Endocrinology chemistry Study of Health in Pomerania Cardiology Population study Female Endothelium Vascular Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Atherosclerosis. 219:875-879 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2011.09.008 |
| Popis: | a b s t r a c t Objective: Small clinical studies suggested a role for aldosterone in the development of endothelial dysfunction. We investigated whether the plasma aldosterone concentration (PAC) or the aldosterone- to-renin ratio (ARR) were associated with decreased endothelial function as measured by flow-mediated dilation (FMD) of the brachial artery in the general population. Methods: Our study population comprised 972 participants from the Study of Health in Pomerania, who were not treated with antihypertensive medication. We performed age-stratified ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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