The relevance of polymeric synthetic membranes in topical formulation assessment and drug diffusion study
| Autor: | Shiow Fern Ng, G.M. Eccleston, Francis Dominic Sanderson, J.J. Rouse |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Drug
Polymers Administration Topical Skin Absorption media_common.quotation_subject Diffusion Drug Evaluation Preclinical Synthetic membrane Models Biological Permeability chemistry.chemical_compound Drug Delivery Systems Silicone Drug Discovery Stratum corneum medicine Humans Polysulfone Skin media_common Chromatography integumentary system Polydimethylsiloxane Organic Chemistry Biological Transport Membranes Artificial medicine.anatomical_structure Membrane Pharmaceutical Preparations chemistry Chemical engineering Diffusion Chambers Culture Molecular Medicine |
| Zdroj: | Archives of Pharmacal Research. 35:579-593 |
| ISSN: | 1976-3786 0253-6269 |
| DOI: | 10.1007/s12272-012-0401-7 |
| Popis: | Synthetic membranes are composed of thin sheets of polymeric macromolecules that can control the passage of components through them. Generally, synthetic membranes used in drug diffusion studies have one of two functions: skin simulation or quality control. Synthetic membranes for skin simulation, such as the silicone-based membranes polydimethylsiloxane and Carbosil, are generally hydrophobic and rate limiting, imitating the stratum corneum. In contrast, synthetic membranes for quality control, such as cellulose esters and polysulfone, are required to act as a support rather than a barrier. These synthetic membranes also often contain pores; hence, they are called porous membranes. The significance of Franz diffusion studies and synthetic membranes in quality control studies involves an understanding of the fundamentals of synthetic membranes. This article provides a general overview of synthetic membranes, including a brief background of the history and the common applications of synthetic membranes. This review then explores the types of synthetic membranes, the transport mechanisms across them, and their relevance in choosing a synthetic membrane in Franz diffusion cell studies for formulation assessment purposes. |
| Databáze: | OpenAIRE |
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