Clinical and pathologic predictors of clinical outcome of malignant pleural mesothelioma

Autor: Agnese Savini, Michela Tiberi, Miriam Caramanti, Stefano Cascinu, Mariagrazia De Lisa, Silvia Rinaldi, Zelmira Ballatore, Francesca Morgese, Azzurra Onofri, Consuelo Ferrini, Rossana Berardi, Ilaria Fiordoliva, Mariangela Torniai
Přispěvatelé: Berardi, R., Fiordoliva, I., De Lisa, M., Ballatore, Z., Caramanti, M., Morgese, F., Savini, A., Rinaldi, S., Torniai, M., Tiberi, M., Ferrini, C., Onofri, A., Cascinu, S.
Rok vydání: 2015
Předmět:
Oncology
Male
Mesothelioma
Cancer Research
Lung Neoplasms
Survival
Ca125
Platinum Compounds
Kaplan-Meier Estimate
Hemoglobins
0302 clinical medicine
Risk Factors
Univariate analysis
medicine.diagnostic_test
Complete blood count
Anemia
General Medicine
Middle Aged
Prognosis
Pemetrexed
Treatment Outcome
Italy
030220 oncology & carcinogenesis
Predictive value of tests
Female
medicine.drug
Adult
medicine.medical_specialty
Pleural Neoplasms
Antineoplastic Agents
Prognostic factors
Disease-Free Survival
03 medical and health sciences
Predictive Value of Tests
Internal medicine
medicine
Humans
Karnofsky Performance Status
Aged
Proportional Hazards Models
Retrospective Studies
Performance status
business.industry
Proportional hazards model
Mesothelioma
Malignant
Retrospective cohort study
medicine.disease
Surgery
030228 respiratory system
CA-125 Antigen
business
Zdroj: Tumori. 102(2)
ISSN: 2038-2529
Popis: Aims and background Although worldwide use of asbestos has decreased, the incidence of malignant pleural mesothelioma (MPM) is expected to increase over the next few decades. A number of scoring systems has been proposed to assess clinicopathologic features and to predict the prognosis. We assessed the relationship between patients’ features and disease evolution in order to choose the best treatment able to prolong overall survival (OS) and progression-free survival (PFS). Methods We retrospectively analyzed patients with locally advanced or metastatic MPM, treated at the Department of Medical Oncology, Università Politecnica Marche, Italy, from January 2003 to September 2013. Data on age, sex, smoking history, asbestos exposure, performance status, tumor stage, histology, type of treatment, and routine laboratory tests including complete blood count panel, date of death, or censored status were collected. The OS and PFS were estimated using Kaplan-Meier method and Cox analysis was performed to analyze the prognostic relevance of clinical parameters. Results We enrolled a total of 62 patients. Univariate analysis showed that histologic type, performance status, response to first-line therapy, pretreatment hemoglobin levels, and plasmatic Ca125 were significant prognostic factors. Conversely, no significant correlation was found between age, sex, smoking history, reported exposure to asbestos, stages at diagnosis, treatments, and OS and PFS. Conclusions Our results showed that anemia and increased Ca125 might be considered negative prognostic parameters in MPM patients and confirmed the prognostic role of histotype, performance status, and response to first-line chemotherapy.
Databáze: OpenAIRE
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